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9th European Congress of Endocrinology

Oral Communications

Thyroid clinical

ea0014oc1.1 | Thyroid clinical | ECE2007

Prevalence of inactivating TSH receptor (TSHR) mutations in a large series of pediatric subjects with non-autoimmune mild hyper-thyrotropinemia (hyperTSH)

Cordella Daniela , Marco Alessandro De , Calebiro Davide , Filippis Tiziana de , Radetti Giorgio , Weber Giovanna , Vigone Maria Cristina , Cappa Marco , Sartorio Alessandro , Busnelli Marta , Bonomi Marco , Chini Bice , Beck-Peccoz Paolo , Persani Luca

Mild hypothyroidism is a heterogeneous and frequent disorder in the general population that is due to autoimmune disease in most of the cases. TSH resistance is considered a rare genetic disease due to germline loss-of-function TSHR mutations. However, TSHR mutations have been mainly searched in patients with large TSH elevations and their actual prevalence among patients with mild TSH elevations (as those found in mild hypothyroidism) is so far unknown. In this study, we eval...

ea0014oc1.2 | Thyroid clinical | ECE2007

Expression gene profile may be useful for the diagnosis of thyroid malignancies

Piampiani Pamela , Romei Cristina , Cosci Barbara , Vivaldi Agnese , Ciampi Raffaele , Viola David , Bottici Valeria , Giannini Riccardo , Basolo Fulvio , Pinchera Aldo , Elisei Rossella

Although 20% of follicular neoplasms are papillary thyroid carcinoma (PTC), their cytological diagnosis is not diagnostic. A different profile of gene expression between malignant and benign thyroid tumors has been reported. Aim of this study was to identify a gene expression profile to be used in distinguishing malignant from benign thyroid neoplasms. By real-time RT-PCR we analyzed mRNA expression of 6 thyroid differentiation genes (TTF-1, PAX8, TPO, TSHr, NIS and Tg) and 5 ...

ea0014oc1.3 | Thyroid clinical | ECE2007

Persistence of decreased peripheral B-lymphocytes after Rituximab treatment is associated to inactive disease in patients with thyroid-associated ophthalmopathy

Campi Irene , Vannucchi Guia , Covelli Danila , Bonara Paola , Currò Nicola , Dazzi Davide , Pirola Giacinta , Rossi Stefania , Guastella Claudio , Beck-Peccoz Paolo , Salvi Mario

The anti-CD20 antibody Rituximab (RTX) induces peripheral B cells depletion. Aim of the present study was to evaluate changes of lymphocytes after RTX therapy, administered at the dosage of 1000 mg twice at 2-week interval, in 10 patients with Graves’ disease, 8 of whom had associated ophthalmopathy (TAO). In all patients, we studied the standard immunophenotypic panel before therapy and monthly for up to 2 years. Total CD20+ (and CD19+) cell depletion was observed after ...

ea0014oc1.4 | Thyroid clinical | ECE2007

A novel tyrosine-kinases selective inhibitor with anti-tumoral efficacy (Sunitinib) induces a block in iodine uptake and transient hypothyroidism

Mannavola Deborah , Vannucchi Guia , Carletto Marco , Longari Virgilio , Bertuelli Rossella , Coco Paola , Casali Paolo , Beck-Peccoz Paolo , Fugazzola Laura

Sunitinib (SU11248) is a multitarget inhibitor of tyrosine-kinases (RTK) recently tested in clinical trials for the treatment of some human cancers. Side effects are mostly represented by asthenia and appear in a dose and time correlated manner. After the unexpected observation of a myxedematous coma in a patient affected with GIST and treated with Sunitinib, we evaluated the effect of this drug on thyroid function in 24 patients treated for GISTs Imatinib resistant. Patients ...

ea0014oc1.5 | Thyroid clinical | ECE2007

CTLA- 4 gene polymorphisms and autoimmune thyroid diseases: meta-analyses of published and individual-level data

Kavvoura Fotini , Akamizu Takashi , Awata Takuya , Ban Yoshiyuki , Chistiakov Dimitry , Frydecka Irena , Ghaderi Abbas , Gough Stephen , Hiromatsu Yuji , Ploski Rafal , Wang Pei-Wen , Ban Yoshio , Bednarczuk Tomasz , Chistiakova Emma , Chojm Marcin , Heward Joanne , Hiratani Hitomi , Juo Suh-Hang Hank , Karabon Lidia , Katayama Shigehiro , Kurihara Susumu , Liu Rue-Tsuan , Miyake Ikuyo , Omrani Gholam-Hossein , Pawlak Edyta , Taniyama Matsuo , Tozaki Teruaki , Ioannidis John PA

Background: CTLA-4 polymorphisms have been widely examined for their associations with autoimmune thyroid diseases (Graves’ disease [GD] and Hashimoto thyroiditis [HT]) but their relative population effect remains unclear.Methodology/Principal findings: Meta-analyses of group-level data from 32 (n=11.019 subjects) and 12 (n=4.479) published and unpublished studies were performed for the association of the A49G polymorphism with ...

ea0014oc1.6 | Thyroid clinical | ECE2007

Sensitization against Soybean may induce an increase in the levels of anti-thyroid peroxidase antibodies in thyroid autoimmunity

Molnár Ildikó

Soybean diet could involve in the development of goitre according to antithyroid effects of isoflavones. Isoflavones from Soybean could induce not only inhibition of thyroid peroxidase (TPO) catalyzed reactions but they are allergens for patients suffering from atopic or autoimmune diseases. Two hundred-sixty patients with thyroid autoimmunity (150 with Graves’ disease, 110 with Hashimoto’s thyroiditis) were investigated for the sensitization against Soybean. Allerge...

ea0014oc1.7 | Thyroid clinical | ECE2007

Pregnant women on thyroxine substitution are often dysregulated in early pregnancy

Hallengren Bengt , Lantz Mikael , Andreasson Bengt , Grennert Lars

Background: Thyroid hormones are important for normal fetal development. The aim of this prospective study was to explore whether thyroxine treated pregnant women with hypothyroidism are adequately thyroxine substituted during pregnancy.Material and method: During the years 1997–2002 119 pregnancies in 101 females with thyroid diseases were followed at the Department of Endocrinology. The diagnoses were autoimmune thyroiditis (AIT) with or without h...