Aim: To study the prevalence of metabolic syndrome (MS) and its relation with ghrelin in old men.
Material and methods: Prospective-population based study (20022005) in which 153 independently living men older than 70 y were included. Comorbidities, physical exam, BMI, blood pressure were recorded and blood sample taken for biochemical and hormonal determinations. Metabolic syndrome was defined using IDF criteria.
Results: MS was found in 54.9%; BMI in non-MS individuals was 25.8±3.3 and in MS was 28.3±3.7 (P<0.001). No association was found between ghrelin and MS at basal evaluation (non-MS 1185±445 vs MS 1106±368; p:ns), even after weight adjustment.
At 3 years follow-up ghrelin level in MS were lower than in non-MS individuals (non-MS 1165.8±356.0 vs MS 988.4±245.8; P:0.004). Differences between ghrelin levels at the two time-points was only statistical significant in MS group (P:0,006). Ghrelin correlated with BMI (r=−0.22; P=.023) in subjects between 7080 years and with creatinina <1.5 mg/dl. Also a correlation was found with HDL (r=0.21; P=.012). Multiple lineal regression analysis showed than age (beta=−12.1; P=.049), BMI (beta=−22.0; P=.021) and creatinine (beta=407.7; P=.002) had an independent effect on circulating ghrelin.
Conclusions: MS in old men is associated to a decrease in circulating ghrelin over time.