ECE2007 Poster Presentations (1) (659 abstracts)
Carotid intima media thickness and bone turnover in type 2 diabetic patients
Seda Sancak 1 , Dilek Yavuz 1 , Ahmet Toprak 2 , Oguzhan Deyneli 1 , Ozlem Tarcin 1 , Dilek Yazici 1 , Hasan Aydin 1 & Sema Akalin 1
1Marmara University Medical School Section of Endocrinology and Metabolism, Istanbul, Turkey; 2Marmara University Medical School Depatment of Internal Medicine, Istanbul, Turkey.
Recent studies indicate that atherosclerotic process is associated with bone metabolism. The aim of this study was to evaluate carotid intima media thickness (CIMT) and its association with bone mineral density and bone turnover markers as well as inflammation markers in type 2 diabetic male patients.
Material-method: 184 type 2 diabetic males (56±8 y) and 85 non-diabetic control subjects (52±7 y) were recruited. Bone mineral density was measured by dual X-ray absorptiometry at lumbar spine and proximal femoral areas. Carotid intima media thickness was evaluated by Doppler ultrasound. Serum osteocalcin, CTX, intact parathyroid hormone (iPTH), hsCRP and HbA1c were measured.
Results are shown in table 1:
| Diabetic subjects | Control subjects | P | |
| Serum calcium (mg/dl) | 9.91±0.4 | 9.8±05 | 0.03 |
| Serum phosphorus (mg/dl) | 3.59±0.57 | 3.39±0.52 | 0.02 |
| Serum PTH (pg/mL) | 49.7±24 | 53±22 | Ns |
| Osteocalcin (ng/ml) | 6.8±3.4 | 9.5±4 | 0.0001 |
| CTX (ng/ml) | 0.27±0.16 | 0.38±0.1 | 0.004 |
| hsCRP (mg/L) | 3.66±4 | 2.11±1 | 0.01 |
| HbA1c (%) | 7.02±1.7 | 5.1±0.32 | 0.0001 |
| Fasting blood glucose (mg/dl) | 151±65 | 92.62±7.9 | 0.0001 |
| Density of Proximal Femur (gr/cm2) | 0.91±0.1 | 0.93±0.1 | 0.4 |
| CIMT (mm) | 0.70±0.16 | 0.61±0.23 | 0.008 |
There was a negative correlation between bone mineral content of femur neck and CIMT in diabetic patients (r=−0, 22 P=0.008).
Conclusion: Atherosclerosis and bone mineral density (BMD) may be related through similar or common pathophysiological mechanisms in type 2 diabetics. Low-grade inflammation may be one of the pathologic mechanisms that depressed bone turnover in diabetic patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more