Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P49

ECE2007 Poster Presentations (1) (659 abstracts)

Deleterious effects of beta-blockers on arterial stiffness and central pulse pressure in menopausal women: baseline findings from the Cashmere trial

S Laurent 2 , S Christin Maitre 1 , A Gompel 3 , P Boutouyrie 2 , P Jaillon 1 , Ch Thuilliez 4 , F Zannad 5 , B Pornel 7 , B Pannier 8 , H Struijker-Boudier 9 , L Van Bortel 10 , Ch Kuntz 11 , A Keanry-Schwartz 5 , I Pithois-Merli 6 , D Simonneau 6 & T Simon 1

1Saint Antoine-UMPC-ParisVI university Hospital, Paris, France; 2HEGP-Paris V-University Hospital, Paris, France; 3Hotel Dieu-Paris V-University Hospital, Paris, France; 4CHU Rouen, Rouen, France; 5CHU Nancy, Nancy, France; 6Pfizer, Paris, France; 7Centre de menopause, Bruxelles, Belgium; 8Department of cardiology, fleury-merogis, France; 9Department of cardiology, Maastricht, Netherlands; 10Department of cardiology, Ghent, Belgium; 11CHU strasbourg, Strasbourg, France.

Beta-blockers (BB) may be less effective than other antihypertensive drugs for stroke prevention in patients with primary hypertension (ASCOT and LIFE studies). Our study compares arterial stiffness and central PP between users (BB+) and non users of BB (BB-), among menopausal women with hypercholesterolemia and no history of CV disease.

Methods and Results: We used the baseline data of 664 menopausal women, screened for the Cashmere study, a12-month double-blind randomized trial comparing the effects of atorvastatin (80 mg/day), vs placebo, ±with hormone therapy, on the progression of CCA-IMT and arterial stiffness. Aortic stiffness was measured by carotid-femoral pulse wave velocity (PWV); central PP and augmentation index (AI, wave reflection) were determined by applanation tonometry; carotid stiffness was calculated from relative stroke change in diameter (echotracking system) and carotid PP. BB were used in 104 women for treating headache, tachycardia, arrhythmia, and hypertension. 97% BB used were devoid of vasodilating properties. Age (60±6 vs 58±5 years, P<0.0001) and mean BP (MBP: 91±12 vs 88±11 mmHg, P<0.0001) were slightly but significantly higher in BB+ than in BB- (n=560). After adjustment to age and MBP, BB+ had 10% higher central PP (P<0.0001), 6% higher AI (P<0.001), 4% higher PWV (P=0.04), and 5% higher carotid stiffness (P<0.01) than BB-. BB+ had 4% higher central SBP (P<0.0001) than BB-, despite a non significantly higher brachial SBP only (1%, P=NS). To rule out an influence of hypertension on arterial parameters, we compared users of anti-hypertensive drugs (n=110) to non users (n=554). No significant difference was observed concerning the above parameters, excluding or not BB- users.

Conclusions: In menopausal women with hypercholesterolemia and no CV disease, the use of non-vasodilating BB was associated with higher aortic and carotid stiffness. These data are consistent with the results of the CAFÉ trial. Whether the deleterious effects of BB on large arteries increase the risk of CV events in women remains to be determined.

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