Endocrine Abstracts

The aim of the research is to study the functional state of liver parenchyma in patients with type 2 diabetes and to analyze hepatobiliary system disorders depending on marker of metabolic syndrome (MS).

The study involved 22 patients with type 2 diabetes and MS and 8 healthy persons. Dynamic hepatoholecystoscintigraphy was performed using RKC 301T gamma camera after Tc-99m mesida administration and bile-expelling meal.

We established a reliable increase of maximum accumulation time of radiopharmaceutical in parenchymatous cells of the liver (22.0±3.76 vs 14.6±0.83, P<0.01) comparing to healthy. Also these patients have infringements of secretory functions that are confirmed by meaningful increase of radionuclide half-deduction time (T1/2) from the liver (60±4.16 vs 45.2±3.49, P<0.03). Also a reliable T1/2 delay occurs in patients with type 2 diabetes and metabolic syndrome comparing to healthy. But in patients with smaller body mass index was found significant lowering of time of radiopharmaceutical occurrence in intestine that testifies the hypotonia of Oddi’s sphincter. In patients with decompensation stage of carbohydrate metabolism comparing to subcompensation occurs meaningful increase of liver T1/2 that points on excretory function delay. Nevertheless we have not found any significant relations between delay of liver excretory function and HOMA, level of C-peptide, triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, WHR, arterial hypertension in patients with type 2 diabetes and metabolic syndrome. Different impacts of per oral hypoglycemic drugs displayed significant lowering of excretory function in patients taking metformin comparing to those who were taking sulfonylurea due to T1/2 elongation of liver (61.75±5.54 vs 39.75±6.62, P<0.05). The obtained findings suggest that absorbing and excretory functions of liver slow down at increase of BMI and decompensation stage in patients with type 2 diabetes and metabolic syndrome. But other markers of metabolic syndrome are not defining in early disturbances of liver excretory function in mentioned patients.