Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P202

1Inonu University Faculty of Medicine Department of Internal Medicine Division of Endocrinology and Metabolism, Malatya, Turkey; 2Inonu University Faculty of Medicine Department of Cardiology, Malatya, Turkey; 3Inonu University Faculty of Medicine Department of Internal Medicine Division of Gastroenterohepathology, Malatya, Turkey; 4Inonu University Faculty of Medicine Department of Biostatistics, Malatya, Turkey.

Objective: The measurement of epicardial adipose tissue (EAT) sonographically is reported to be related with both obesity and insulin resistance. Hepatic steatosis is one of the best known other coincidence with obesity. We aimed to evaluate the relationships between EAT thickness, hepatic steatosis and insulin resistance in obese patients.

Methods: Obese 63 subjects were enrolled into the study. Local ethical committee approval was obtained. Patients were divided into three groups according to body mass index (BMI) as follows: 20 patients with 30≤BMI<35 kg/m2 (Group 1, mean age 39.3±12.9 yrs), 25 patients with 35≤BMI<40 kg/m2 (Group 2, mean age 41.7±9.3 yrs), and 18 patients with BMI≥40 kg/m2 (Group 3, mean age 36.8±13.9 yrs). EAT thickness and grade of hepatic steatosis were assessed sonographically. Anthropometrical measurements were assessed with the foot-to-foot bioelectrical impedance analysis. Insulin resistance was assessed according to basal insulin, QUICKI and HOMA equations.

Results: hsCRP was the only metabolic parameter; which was higher in Group 3 than Group 1 significantly (P=0.02). EAT thickness was similarly higher in both groups 2 and 3; but groups were found to be similar for grade of hepatic steatosis. Both EAT thickness and grades of hepatic steatosis were positively and significantly correlated with whole body fat mass and abdominal adiposity. Waist circumference was the only factor affecting EAT thickness in linear regression analysis.

Conclusion: Grade of hepatic steatosis is a lesser sensitive marker for closer obesity levels than EAT, but with its significant correlations; hepatic steatosis can also be assessed as a valuable predictor for reflecting increments of whole body fat mass and abdominal adiposity as EAT thickness.

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