Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P227

ECE2007 Poster Presentations (1) (659 abstracts)

Acute phase reactants and soluble cell adhesion molecules are associated to plasma leptin levels in obese nondiabetic children

Barbara Garanty-Bogacka , Malgorzata Syrenicz , Anhelli Syrenicz , Aneta Gebala , Grazyna Dawid & Mieczyslaw Walczak


Pomeranian Medical University, Szczecin, Poland.

There are increasing evidences that leptin, a protein secreted by adipose tissue, may be an important factor contributing to the development of atherosclerosis. In this study, the relationship between plasma leptin levels and markers of inflammation and endothelial activation was investigated in 214 obese nondiabetic children and adolescents. Fasting levels of leptin, C-reactive protein (CRP), fibrinogen (FB), interleukin-6 (IL-6), interleukin-1β (IL-1β), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), von Willebrand factor (vWF), glucose and insulin were determined. Insulin resistance was assessed by the homeostasis model. At multiple regression analysis leptin predicted IL-6, FB, ICAM-1, VCAM-1 and vWF independently of obesity measures and HOMA IR. There was a trend for association between leptin and CRP concentrations. Therefore, our findings showed that leptin levels is associated with inflammation and endothelial activation markers and in such way may promote the development of attherosclerosis relatively early in life

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