Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.
Subjects and methods: A total of 117 apparently healthy subjects were included to the study (age 2068 year, mean age: 43±12, BMI:30.1±7.99 kg/m2). Carotid Intima-media thickness (IMT) was measured with ultrasonography. Subjects were divided into two groups according to their IMT higher than 1 mm (group-1) or not (group-2). Total cholesterol, LDL-cholesterol, triglycerides, Hs-CRP, interleukin-1β, interleukin2, interleukin 6, interleukin 8, Tumour necrosis factor α, BMI, body fat mass with bioelectric impedance and body fat distribution (waist and hip circumference) of two groups were compared with independent t test.
Results: BMI, body fat mass, hip circumference, plasma LDL cholesterol, Hs-CRP levels of group-1 were higher than group-2 (
Conclusions: 1-Carotid intima media thickness are closely related increased BMI, fatmass, hip circumference and LDL-cholesterol levels.
2-Hs-CRP is a useful marker of atherosclerosis.
|Group-1 (n=17)||Group-2 (n=100)||P value|
28 Apr - 02 May 2007
European Society of Endocrinology