Our previous studies made between 19992003 demonstrated that County Mures is a moderate/mild iodine-deficient geogra-phical area. In 2002 a governmental decision was given for universal iodization of alimentary salt with increased iodine-content, realized during 2004. The aim of our study was to investigate the effect of in-creased iodine-supplementation at school children living in different iodine-deficient areas in County Mures, through urinary iodine excretion (UIE). In December 2005 were tested 50 school-children from a rural mountain area, while in October 2006 other 133 children from surrounding villages: 55 from Casva, 28 from Glajarie and 50 from Ibanesti.
The group tested in 2005 had mean UIE of 56.00±38.07 μg/L, only 6% of children having normal values. The group studied in October 2006 had mean UIE of 85.37±60.05 μg/L, only 30.8% having normal values, 38.3% between 5099 μg/L, 22.6% between 2049 μg/L (mild and moderate dec-re-a-se), and 8.3% under 20 μg/L (very low levels). Thus, 69.2% of child-ren had subnormal levels, and the percentage of UIE <50 μg/L reached 30.8%, which is above 20%, the upper admitted limit for an adequate iodine-intake. Our results from 2005 are similar with those obtained by Balazs et al. in 1999 in the superior and middle hydrographic basin of the river Mures (mean value 59.95±30.22 μg/L, normal UIE in 6.9%) at a group of 58 school-children from zone of locality Deda. At the same time, our recent results (October 2006) are much better: the mean value rose to 85.37±60.05 μg/L and 30.8% of children had normal UIE. Ana-lysing separately the groups of villages, the results are somehow different: 72.90±48.63 μg/L in Casva, 75.42±60.30 μg/L in Glajarie and 109.83±73.22 μg/L in Ibanesti.
In conclusion, the rural mountain zones of County Mures known before as moderate/mild iodine-deficient areas, became mild deficient, due to the new measures of iodine prophylaxis. In these areas is necessary to apply permanently special prophylactic measures, too.