Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P381

ECE2007 Poster Presentations (1) (659 abstracts)

Resistin levels in hypothyroid patients before and after treatment &br;with thyroxin

Marianthi Tzoitou 1 , Evridiki Papadopoulou 1 , A Galactidou 2 , Athanasios Papageorgiou 1 , Anargyros Kourtis 1 , Marina Kita 1 , louiza ventzi 1 & Avraam Avramidis 1

1Endocrinology Department, Hippokratio General Hospital, Thessaloniki, Greece; 2Research Department of Theagenio Hospital, Thessaloniki, Greece.

Introduction: Resistin is a peptide hormone that is secreted from fat cells and its secretion is regulated from hormonal and dietary factors. In hypothyroid patients its levels are decreased.

The purpose of this study is to evaluate the levels of circulating resistin in hypothyroid patients before and after thyroid function is normalized with thyroxin therapy.

Materials and methods: Twenty (20) hypothyroid patients (2M, 18F) mean aged 49.9±12.4 and mean weight 75.1±19.4 Kgr) were studied.

FT4, TSH, AMA, ATA, Resistin were measured before and three months after thyroxin therapy.

Results: Resistin levels do not change significantly (5.8±4.1 vs 5.1±3.4 μg/lt).All patients became euthyroid after three months of treatment and TSH, FT4, AMA, ATA levels were changed significantly(16.7±3.4 miu/lt vs1.2±0.2 miu/lt, 0.8±0.07 ng/dl vs1.3±0.07 ng/dl and 1579.6±653 vs 412±219. 441.8±205 vs 264.8±111). The body weight of the patients was not change significantly during therapy( 75.1±19.4 vs 74.1±17.2 Kgr).

Conclusions: Normalization of thyroid function did not affect resistin levels significantly. Possibly this is because there was no change IN the patients weight during treatment.

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