Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P398

ECE2007 Poster Presentations (1) (659 abstracts)

Correlation between bone minerale density and bone turnover in delayed puberty

Iulia Bistriceanu , Marian Bistriceanu , Elena Neacsu , Magda Preda & Alida Pruna

Craiova University of Medicine and Pharmacy, CRAIOVA / DOLJ, Romania.

It is established that the delayed puberty is the lack of development of sexual maturation in boys and girls at a chronological age that is 2.5 standard deviation above the mean age. Some possible causes of delayed puberty are: hypothalamic defects, pituitary defects or the gonads.

Objectives: Early diagnosis of the gonadal insufficiency; identification of the bone mass and the bone turnover at the pacients with delayed puberty; prophylaxis measures of the bone modification still in pre, puberal and postpuberal stage which lead to a maximal bone mass in correlation between sex and age.

Materials and methods: The study group includes 23 patients with age under 17–22 years with next forms of delayed puberty: Turner syndrome (8), gonadotropin deficiency (8), growth hormon deficiency with gonadal defects (5), nonsecreting pituitary tumors - the chromophobe adenoma (2). The diagnosis of osteoporosis was besed on BMD measurement using dual energy X-ray absorptiometry (DEXA). The cases were evaluated and diagnosed using the determination of levels seric of bone resorption represented by C-terminal telopeptide of tip I procollagen (CrossLaps) and as marker of bone formation represented by osteocalcine.

Results: Osteoporosis was found in 9 (T-score between −2.73 and −3.50), 7 presents osteopenia (T-score between −1.70 and −2.30) and 7 have normal BMD. The Crosslaps (1.054–2.1 ng/ml) and the calcitonina (47–149 ng/ml) were increased in osteoporosis and the results are comparative with postmenopausal women value, the pacients with osteopenia had identical results with premenopausal women value (osteocalcine 22.91–24.94 ng/ml, Crosslaps 0.179–0.250 ng/ml).

Conclusion: Early diagnosis of gonadic failure in order to stabilize/increase the bone mass and to reduce the fractures’ incidents, osteoporosis/osteopenia therapy associates estroprogestative/androgenic substitution with specific means of the bone remineralization (biphosphonates, calcium formulas and vitamin D derivates)

Keywords: delayed puberty, BMD, osteocalcine, Crosslaps.

Article tools

My recent searches

No recent searches.