Introduction and Aim: Polycystic Ovary Syndrome (PCOS) is an endocrine disease closely related to several risk factors for cardiovascular disease. Previous study demonstrated an impaired cardiopulmonary functional capacity in PCOS women. The present study was performed to evaluate the effects of 3-months exercise training (ET) programme on cardiopulmonary functional capacity in young women with PCOS.
Patients and Methods: The study was conducted according to the guidelines of the Declaration of Helsinki, and the institutional ethical committee approved the study protocol. The purpose of the protocol was explained to each subject, and written informed consent was obtained from each patient before beginning the study.
Ninety young PCOS women were randomly subdivided into two groups each composed of 45 subjects: PCOS-T (trained) group (age=21.7±2.3 years, BMI=29.3±2.9) underwent 3-months ET whereas PCOS-UnT (untrained) group (age=21.9±1.9 years, BMI=29.3±3.1) did not. At baseline and after 3 months, all patients were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test.
Results: After 3-month ET, PCOS-T showed a significant improvement in peak oxygen consumption (+35.4%, P<0.001) and in maximal workload (+37.2%, P<0.001). In PCOS-T we also observed a significant reduction of BMI (−4.5%, P<0.001) and C-reactive protein (−10%, P<0.001), and a significant (P<0.001) improvement of insulin sensitivity indexes. After 3 months, no changes were observed in PCOS-UnT.
Conclusions: Three-months ET improves cardiopulmonary functional capacity and insulin sensitivity in young PCOS women.