ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2007) 14 P634

Abnormal heart rate recovery after maximal cardiopulmonary exercise stress testing in polycystic ovary syndrome

Francesco Giallauria1, Stefano Palomba2, Teresa Cascella3, Alessandra Vitelli1, Luigi Maresca1, Alessandra Grieco3, Domenico Tafuri4, Annamaria Colao3, Gaetano Lombardi3, Carlo Vigorito1 & Francesco Orio5

1Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Cardiac Rehabilitation Unit, Institute of Internal Medicine and Metabolic Disease, “Federico II” University of Naples, Naples, Italy; 2Department of Obstetrics and Gynecology, University “Magna Graecia” of Catanzaro, Catanzaro, Italy; 3Department of Molecular & Clinical Endocrinology and Oncology, “Federico II” University of Naples, Naples, Italy; 4Teaching and Methods of Sportive Activity, “Parthenope” University of Naples, Naples, Italy; 5Endocrinology, Faculty of Motor Science, “Parthenope” University of Naples and Department of Molecular & Clinical Endocrinology and Oncology, “Federico II” University of Naples, Naples, Italy.

Introduction and aim: Polycystic ovary syndrome (PCOS) is associated with an adverse metabolic and cardiovascular risk (CVR) profile, including: diabetes, insulin resistance, dyslipidemia and hypertension. Heart rate recovery (HRR) is a measure of autonomic dysfunction and an abnormal HRR is also associated with increased mortality. To date, no evaluation of autonomic function in young PCOS women has been performed, therefore the aim of the present study was to evaluate the HRR in PCOS.

Patients and methods: The study was approved by the local Ethical Committee. Forty-eight PCOS patients matched with 48 healthy women mean age (21.7±2.2 vs. 21.9±1.8, yrs±SD, respectively) and body mass index (29.5±3.1 vs. 29.7±3.6, kg/m2 ± SD, respectively). Hormonal and metabolic pattern, cardiopulmonary functional capacity, as expressed by: maximal oxygen consumption (VO2max) and oxygen consumption at anaerobic threshold (VO2AT), and autonomic function, as expressed by HRR, were evaluated.

Results: In PCOS women we observed a significant (P<0.001) abnormal HRR (12.7±2.1 vs. 20.8±3.1 beats/min), and a significant impairment of: VO2max (17.9±2.3 vs. 29.0±3.9, ml/Kg/min) and VO2AT (13.1±2.6 vs. 24.1±3.1, ml/Kg/min) compared to healthy women. In PCOS patients, abnormal HRR was inversely correlated to BMI (r=−0.700, P<0.0001), HOMA (r=−0.680, P<0.0001) and AUCINS (r=−0.640, P<0.0001).

Conclusions: Our data are the first to demonstrate an abnormal HRR after maximal cardiopulmonary exercise stress testing in young overweight PCOS patients, adding HRR as a further potential marker of increased CVR in PCOS.