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Endocrine Abstracts (2007) 14 P651

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Baskent University, Ankara, Turkey.


Increased plasma concentration of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, has been associated with cardiovasular risk factors. The aim of this study was evaluate plasma ADMA levels and subclinical atherosclerosis in patients with polycystic ovary syndrome (PCOS) and healty controls.

Thirty-five patients with PCOS and age, body mass index (BMI) matced thirty-one healty subjects were included in the study.PCOS was defined according to Rotterdam criterion. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfat (DHEAS), free testosterone and total testosterone were measured. Serum insulin and plasma glucose levels measured at baseline before the oral glucose tolerance test. Insulin resistance was evaluated by homeostasis model assesment (HOMA IR). Also serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL C), triglycerides (TG), homocysteine, fibrinogen, C reactive protein(CRP) were determined. Plasma ADMA levels were measured. Intima media thickness (IMT) assessment of the common carotid artery (CCA) were performed ultrasonographically.

The PCOS group had higher levels of androgens, TG, homocysteine, insulin, and HOMA IR. (P<0.05). There were no significant differences in ADMA levels and IMT between two groups. Also FPG, TC, HDL C, LDL C, fibrinogen and CRP levels were not different among the groups (P>0.05). IMT was significantly correlated with DHEAS but no association was determined with ADMA.

To our knowledge, this is the first study that assessed ADMA levels in patients with PCOS. The results of the study showed that ADMA levels and IMT were not different in PCOS patients from healty controls.

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