Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P66

ECE2007 Poster Presentations (1) (659 abstracts)

Comparison of twice daily NPH insulin versus once daily glargine insulin in the frequency of nocturnal hypoglycemia in Type2 diabetic patients with congestive heart failure

Neslihan Kurtulmus 1 , Fatma Demirdogen 2 & Tufan Tukek 2


1Vakif Gureba Educational Hospital, Department of Endocrinology, Istanbul, Turkey, 2Vakif Gureba Educational Hospital, Department of Internal Medicine, Istanbul, Turkey.

Aim: We had the aim to determine the insulin treatment strategy that could prevent or decrease the occurrence of hypoglycaemia while providing better regulation of blood glucose in Tip 2 diabetic patients with cardiac failure.

Method: The patients demonstrating similar characteristics with respect to the age, body mass index, the duration of diabetes and heart failure were randomized into two groups as insulin glargine (n: 19) and NPH (n: 11). The subjects have been prospectively followed up for 12 weeks.

Results: Basal blood glucose level was detected as 197.21±69.01 in insulin glargine group(group1), it was 175.45±52.26 in NPH insulin group(group2) (P=0.339). Basal postprandial blood glucose in group1 was found to be 191.42±63.42, it was 186.18±81.82 In group2 (P=0.857). The nocturnal(3.00 am) blood glucose was 191.42±63.42 in group1, it was 186.18±81.82 in group2 (P=0.857). In group1, basal HbA1c value was 8.11±1.98, which was found to be 7.88±1.49 in group2 (P=0.728). At week 12 of insulin therapy, HbA1c value was 6.86±1.59% in group1, markedly decreased compared to initial HbA1c value (P<0.001). In NPH group, HbA1c was found to be 7.31±1.36% at week 12, which was also lower than that at the beginning of the treatment, however this result was not statistically significant (P=0.417). The frequency of nocturnal hypoglycaemia in group1 was detected to be 10.5%, compared to 9.1% in group2. In two groups did not show any statistical difference related to the frequency of nocturnal hypoglycaemia.

Conclusion: In our study, while the use of insulin glargine provided a better metabolic control compared to NPH insulin,but it failed to decrease the frequency of nocturnal hypoglycaemia in diabetic subgroup with cardiac failure.

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