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Endocrine Abstracts (2007) 14 P85

Institute of endocrinology, diabetes and diseases of metabolism, Belgrade, United States.

Patients with primary hyperparathyroidism (PHPT) are insulin resistant. The effect of PHPT on lipid levels and low-grade inflammation leves is unknown. The aim of our study was to estimate the cardiovascular risk profile in patients with PHPT. Methods: In patients with PHPT (N=19; age: 58.15±8.38 years; PTH 180.83±104.15 ng/l, calcium 2.97±0.19 mmol/l) insulin sensitivity (measured using euglycemic hyperinsulinemic clamp - M value), lipids (total cholesterol, HDL-C, LDL-C, triglycerides, ApoA1 and ApoB) and CRP levels were measured. Results: There were low-normal level of insulin sensitivity (M value: 4.29±0.52), slightly elevated levels of total cholesterol (6.07±1.39 mmol/l) and LDL-C (3.72±1.04 mmol/l) and normal levels of HDL (1.28±0.08 mmol/l), triglycerides (1.80±0.19 mmol/l), ApoA1 (1.54±0.09 g/l), ApoB (1.19±0.09 g/l) and CRP (1.58±0.52 mg/dl) levels. There were negative correlations between M index and total cholesterol (r=−0.56, P<0.05) and Apo B (r=−0.77, P<0.05) levels, while there was positive correlation between PTH and CRP levels (r=0.55, P<0.05). In conclusion, low-normal insulin sensitivity and elevated levels of total holesterol and LDL-C were observed in our group of patients with PHPT. Further evaluation of low-grade inflammation is necessery in this group of patients.

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