Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2008

Poster Presentations

Neuroendocrinology and behaviour

ea0015p203 | Neuroendocrinology and behaviour | SFEBES2008

Carcinoid syndrome presenting as chronic diarrhoea in a 88 year old lady with possible primary in the liver

Koshi I , Zachariah S , Schiff R

We present the case of 88 year old lady who presented with long standing history of diarrhoea (18 months). She had been previously investigated under the gastroenterologists with various tests including upper GI endoscopy and colonoscopy. In view of deterioration of symptoms she was admitted under the geriatric team as she could no longer cope with the diarrhoea. On examination she looked well and had fullness in the right hypochondrial region. Blood tests showed abnormal live...

ea0015p204 | Neuroendocrinology and behaviour | SFEBES2008

Increased desire for food when fasted is associated with increased activation of the ventral striatum, insula and amygdala in humans

Goldstone Anthony P , de Hernandez Christina Prechtl , Muhammed Kinan , Bell Gabriel , Durighel Giuliana , Hughes Emer , Waldman Adam D , Bell Jimmy D

Using functional MRI, we examined how regional brain activity varies with nutritional state when viewing food pictures of different caloric density and appeal.Eighteen non-obese healthy volunteers (BMI 22.2±0.5 kg/m2, age range 19–36 years, 8 male) were studied on 2 separate mornings after an overnight fast (mean±S.E.M. 15.5±0.3 h) or when fed (1.2±0.1 h after breakfast, food intake 45±4% of estimat...

ea0015p205 | Neuroendocrinology and behaviour | SFEBES2008

The influence of sex steroids on cognitive ability in pregnancy

Farrar Diane , Neil Jo , Tuffnell Derek , Marshall Kay

Background: Ovarian steroid action is not limited to the gonadal–pituitary–hypothalamic axis. A recent pre-clinical investigation by Sutcliffe et al. (2007) suggests female sex steroids influence learning and memory strategies. However, data from human trials involving various hormone replacement regimens and assessment of memory in pregnancy appear equivocal.Pregnancy allows overriding of regulatory feedback loops leading to elevation o...

ea0015p206 | Neuroendocrinology and behaviour | SFEBES2008

High prevalence of sleep apnoea in craniopharyngioma patients after surgical intervention

Crowley Rachel K , Woods Conor , Fleming Michelle , Rogers Bairbre , Costello Richard W , Thompson Christopher J

Patients with craniopharyngioma have increased mortality attributed to cardiorespiratory disease, when compared to other hypopituitary populations. There is little data on the cause for excess of fatal respiratory disease in this condition. Clinical observation had identified sleep apnoea in some craniopharyngioma patients in our cohort. Sleep apnoea increases cerebrovascular and cardiovascular morbidity and mortality. Our hypothesis was that sleep apnoea could be a contributo...

ea0015p207 | Neuroendocrinology and behaviour | SFEBES2008

Persistent AVP production and hyponatraemia in a male infant with an activating mutation of the AVPR2 and his heterozygous mother: new insights into NSIAD

Gupta Sanjay , Cheetham Tim , Roberts Cathe rine , Bourn David , Lambert Heather , Coulthard Malcolm , Ball Steve

Introduction: The Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is an X-linked condition characterised by reduced renal water clearance and hyponatraemia resulting from gain of function mutations in the type 2 Vasopressin (AVP) receptor (AVPR2). Female carriers were thought not to express a phenotype. We describe a kindred with NSIAD, highlighting molecular and physiological characteristics that extend understanding of this condition and of AVP production.<p c...

ea0015p208 | Neuroendocrinology and behaviour | SFEBES2008

Craniopharyngioma: a single institutional experience from South India

Sivan Arul Selvan S , Felix Jebasingh K , Rajaratnam Simon , Thomas Paul V , Thomas Nihal , Mandalam Subramaniam Seshadri , Simon Anna , Chacko Ari George , Vedantam Rajshekhar , Thomas Daniel Roy

Introduction: Craniopharyngiomas constitute 2–5% of all primary CNS neoplasms. We retrospectively analysed the case records of all patients with craniopharyngioma treated in our hospital from 1996 to 2006.Results: One hundred and twenty-seven patients were treated during this period. 65% were male and 35% were female. 50 patients (39%) were <15 yrs of age. The maximum clustering of cases was in the 6–15 yr age group (37%).<p class="abs...

ea0015p209 | Neuroendocrinology and behaviour | SFEBES2008

The physiological response of Peptide YY following orlistat

Bhogal Randip S , Roux Carel W Le , Ahweyevu Rukevwe A , Bloom Steve R , Ghatei Mohammad A

Background: Orlistat is a lipase inhibitor used in the treatment of obesity. Recent published work has shown that orlistat may have a role in affecting the release of appetite regulating gastrointestinal derived peptides. However, the precise effect of orlistat on these hormones remains uncertain. This study aimed to evaluate the short-term effects of orlistat with a high fat meal on levels of plasma Peptide YY (PYY) and on appetite.Methods: Ethical perm...

ea0015p210 | Neuroendocrinology and behaviour | SFEBES2008

Effect of social isolation on hypothalamo–pituitary–adrenocortical axis reactivity

Salam Menai , Buckingham Julia C , John Christopher D

Animals that are socially isolated for extended periods show behavioural and physiological changes, including alterations in hypothalamo-pituitary-adrenocortical (HPA) activity. However, there is conflicting data regarding the effects of social isolation on the HPA axis, with studies indicating increased1, decreased2 and unchanged3 corticosterone levels following social isolation. We investigated the effects of social isolation on HPA activity ...

ea0015p211 | Neuroendocrinology and behaviour | SFEBES2008

The influence of Annexin A1 on the apoptosis of PC12 cells

Kasivisvanathan Veeru , McArthur Simon , Gillies Glenda , Solito Egle

The main pathological finding in Parkinson’s disease (PD) is the loss of dopaminergic cells in the substantia nigra (SNc). Current dopamine-replacement therapies alleviate symptoms but do not prevent disease progression. The pathophysiology of PD is unknown, but oxidative stress and neuroinflammation have been implicated. A better understanding of the cause of dopaminergic cell death may lead to the discovery of new therapies that can slow disease progression.<p class...

ea0015p212 | Neuroendocrinology and behaviour | SFEBES2008

Neurosarcoidosis presenting as secondary hypogonadism

Kannappan Daniel , Hay Cathy

History: A 36 year old gentleman was referred to the endocrine clinic with symptoms of fatigue, absent libido and erectile dysfunction. He had a previous history of pulmonary sarcoidosis in 2000 and he was taking no medications. Examination revealed a known Right sided Horner’s syndrome and no other abnormality.Investigations: Testosterone 1.8 nmol/l, FSH and LH<0.5, Prolactin 798 mU/l, Cortisol 507 nmol/l, ACE 67 (47–60 IU/l), CSF protein ...

ea0015p213 | Neuroendocrinology and behaviour | SFEBES2008

Preservation of sexual dimorphism and diurnal variation in leptin levels of patients with craniopharyngioma

Crowley Rachel K , Woods Conor , Fleming Michelle , Rogers Bairbre , O'Sullivan Eoin P , Smith Diarmuid , Thompson Christopher J

Leptin is an adipocytokine with a role in appetite, energy expenditure and reproductive regulation. In normal, non-obese individuals, leptin levels are higher in females, independent of differences in body fat between the genders. High levels of leptin that were disproportionate to body mass index (BMI) have been reported in craniopharyngioma patients, thus we hypothesised that surgical resection and hypothalamic damage conferred leptin resistance on craniopharyngioma patients...