Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 16 | ECE2008 | Next issue

10th European Congress of Endocrinology

Oral Communications

Neuroendocrinology and pituitary

ea0016oc1.1 | Neuroendocrinology and pituitary | ECE2008

Structured assessment of neuroendocrine dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage in 921 patients: the German Interdisciplinary Database

Schneider Harald , Schneider Manfred , Tuschy U , Wallschofski Henri , Faust Michael , Renner C , Kopchak Anna , Jordan Martina , Saller Bernhard , von Rosen Friedrich , Kreitschmann-Andermahr Ilonka , Buchfelder Michael , Stalla Gunter Karl

Background: Recent studies show that traumatic brain injury (TBI) and aneurysmal subarachnoid hemorrhage (SAH) are frequent causes of long-term disturbances of hypothalamo–pituitary function. Still little is known about risk factors and clinical characteristics of pituitary impairment after brain damage. This study aimed to address these questions on a larger scale by establishing a national registry of these patients.Methods: All centers treating p...

ea0016oc1.2 | Neuroendocrinology and pituitary | ECE2008

The adequacy of thyroxine replacement in hypopituitary patients

Filipsson Helena , Feldt-Rasmussen Ulla , Kourides Ione , Popovic Vera , Koltowska-Haggstrom Maria , Jonsson Bjorn , Johannsson Gudmundur

Background: Hypopituitary patients with untreated growth hormone deficiency (GHD) have increased fat mass, dyslipidaemia and insulin resistance. Inappropriately low thyroxine doses in patients with central hypothyroidism (CH) may also promote such clinical features.Objective: To examine metabolic outcome of thyroxine replacement in hypopituitary patients before and after GH replacement.Method: One thousand and six hundred and two p...

ea0016oc1.3 | Neuroendocrinology and pituitary | ECE2008

Limited effects of growth hormone replacement in adults with growth hormone deficiency after treatment for acromegaly

van der Klaauw Agatha , Bax Jeroen , Stokkel Marcel , Bleeker Gabe , Roelfsema Ferdinand , Smit Johannes , Romijn Johannes , Pereira Alberto

Growth hormone deficiency (GHD) can occur after treatment for acromegaly. It is unclear whether treatment with recombinant human growth hormone (rhGH) in these patients is beneficial. Patients were randomized to either 1 year of rhGH replacement (n=10) or placebo followed by rhGH replacement for 1 year (delayed rhGH treatment, n=6). Sixteen patients (8 men, mean age 56 years) with GHD after treatment for acromegaly were studied. Study parameters were assessed at ...

ea0016oc1.4 | Neuroendocrinology and pituitary | ECE2008

Pasireotide (SOM230) effectively reduces pituitary tumor volume in patients with active acromegaly: preliminary 6-month results from a phase II extension study

Farrall Andrew J , Glusman Joan E , Ruffin Matthieu , Petersenn Stephan

Introduction: In a recent 16-week Phase II study in patients with de novo, persistent or recurrent acromegaly, pasireotide effectively controlled GH and/or IGF-I levels in 56% of patients, and reduced tumor volume by >20% in 39% of patients. We present preliminary 6-month results from the ongoing extension phase of this study.Methods: This extension study enrolled patients who achieved biochemical control (GH ≤2.5 μg/l and normalize...

ea0016oc1.5 | Neuroendocrinology and pituitary | ECE2008

Cardiac performance after long-term treatment with Pegvisomant in patients with acromegaly: a radionuclide angiography study

Auriemma Renata Simona , De Martino Maria Cristina , Galdiero Mariano , Acampa Wanda , De Leo Monica , Lombardi Gaetano , Cuocolo Alberto , Colao Annamaria , Pivonello Rosario

GH and IGF-I excess causes a specific cardiomyopathy, often complicated by diastolic and systolic dysfunction until heart failure. The aim of this study is to evaluate the effects of long-term treatment with pegvisomant on cardiac performance in acromegalic patients. Twelve patients (4 men and 8 women, age 29–58 years) entered the study. A radionuclide angiography at rest and during exercise was performed at baseline and after 18 months of treatment with pegvisomant with ...

ea0016oc1.6 | Neuroendocrinology and pituitary | ECE2008

The metabolic effects of ghrelin and glucocorticoids are mediated by AMP-activated protein kinase (AMPK) and endogenous cannabinoids

Kola Blerina , Christ-Crain Mirjam , Farkas Imre , Wittmann Gabor , Lolli Francesca , Seboek Dalma , Harvey-White Judith , Kunos George , Muller Beat , Arnaldi Giorgio , Giacchetti Gilberta , Boscaro Marco , Grossman Ashley B , Fekete Csaba , Korbonits Marta

Ghrelin, cannabinoids and glucocorticoids have all orexigenic and widespread metabolic effects. AMPK is a major controller of many metabolic processes. We have studied the effects of ghrelin and glucocorticoids and their interaction with endocannabinoids using cannabinoid-receptor-1 (CB1) knock-out mice and CB1 antagonist-treated mice, and using tissue samples from patients with Cushing’s syndrome and from a rodent model of Cushing’s syndrome. AMPK activity and downs...

ea0016oc1.7 | Neuroendocrinology and pituitary | ECE2008

Intermittent high glucose concentrations reduce neuronal precursor proliferation by altering the IGF system: the involvement of the neuroprotective factor seladin-1

Giannini Stefano , Pezzatini Anna , Luciani Paola , Manuelli Cinzia , Benvenuti Susanna , Cellai Ilaria , Deledda Cristiana , Vannelli Gabriella Barbara , Rotella Carlo Maria , Serio Mario , Peri Alessandro

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...

ea0016oc1.8 | Neuroendocrinology and pituitary | ECE2008

Differential sensitivity of men and women to anorexigenic and memory improving effects of intranasal insulin

Benedict Christian , Kern Werner , Schultes Bernd , Born Jan , Lehnert Hendrik , Hallschmid Manfred

Background: Central nervous insulin is critically involved in the regulation of body weight and memory processing. Long-term administration of intranasal insulin reduces body weight in men but not in women while improving hippocampus-dependent memory processing in both genders. Here, acute effects of intranasal insulin on food intake and memory functions were studied in men and women.Methods: Thirty-two healthy, normal-weight subjects (14 men, 18 women) ...

ea0016oc1.9 | Neuroendocrinology and pituitary | ECE2008

Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men

Vila Greisa , Clodi Martin , Geyeregger Rene , Riedl Michaela , Stulnig Thomas M , Struck Joachim , Luger Thomas A , Luger Anton

Oxytocin is a hormone and neurotransmitter with antiinflammatory and neuroimmune-modulatory properties. Physiological states of elevated plasma oxytocin levels are associated with reduced hypothalamic–pituitaty–adrenal response to different stressors. We examined the effect of exogenous oxytocin administration on bacterial endotoxin induced innate immune responses in humans. Ten healthy men received in a randomized, placebo-controlled, cross-over design (1) placebo, ...