Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 16 | ECE2008 | Next issue

10th European Congress of Endocrinology

ea0016oc2.1 | Thyroid | ECE2008

Analysis of early gene expression in mouse thyroid development

Hubner Caroline , Weber Martin , Biebermann Heike , Herrmann Bernhard , Gruters Annette , Krude Heiko

Background: Defective thyroid gland development occurs in 80% of congenital hypothyroidism (incidence of 1:3000–1:4000). Only <5% have been shown to be caused by molecular genetic defects in few transcription factor genes (Nkx2.1, Nkx2.5, Foxe1, Pax8, Hhex) which are known to play a role in thyroid gland development. Therefore, other genes with a critical role in early thyroid development are likely to be involved in the pathogenesis of thyroid dysgenesis.<p class...

ea0016oc2.2 | Thyroid | ECE2008

Identification of 25 novel NKX2-1 gene mutations in 100 patients with broad spectrum of brain and thyroid dysfunctions

Thorwarth Anne , Schnittert Sarah , Jyrch Sabine , Dame Christof , Biebermann Heike , Grueters Annette , Krude Heiko

Objective: The NKX2-1 gene, also known as TITF-1, TTF-1 or T/ebp, is a member of the homeodomain-containing NK-2 transcription factor gene family and expressed in early development of thyroid, lung and forebrain. Initial screening of patients with isolated congenital hypothyroidism failed to show mutations. The first human heterozygous deletion affecting the NKX2-1 gene to be reported was a neonate with respiratory failure, primary hypothyroidism and neurological signs matchin...

ea0016oc2.3 | Thyroid | ECE2008

Global proteomic analysis in human thyroid proliferative/neoplastic primary culture lines

Bravo SB , Garcia-Rendueles MER , Ciordia S , Juarez S , Paradela A , Cameselle-Teijeiro J , Albar JP , Alvarez CV

Proteomics provides an avenue to understand the interaction between the functional pathways within a cell and its environmental milieu, independent of any changes at the RNA level. There are only a few studies in thyroid diseases using proteomics; variability in specimen content in fibrous versus follicular tissue plus the presence of other types of cells (blood, lymphatic) makes difficult to apply global proteomic to surgery pieces; commercial cell-lines of thyroid cancer wer...

ea0016oc2.4 | Thyroid | ECE2008

Identification and enrichment of thyroid stem cells in anaplastic cell lines

Zito Giovanni , Richiusa Pierina , Pizzolanti Giuseppe , Bommarito Alessandra , Carissimi Elvira , Coppola Antonina , Nucera Miriam , Galluzzo Aldo , Giordano Carla

In the last years, a growing body of evidence supports the notion that tumors are organized in a hierarchy of heterogeneous cell populations with different biologic properties and that the capability to sustain tumor formation and growth exclusively resides in a small proportion of tumor cells, termed cancer stem cells (CSC). The existence of CSC was first proven in the context of acute myelogenous leukaemia, and subsequently verified in brain, breast, colon and prostate cance...

ea0016oc2.5 | Thyroid | ECE2008

Fetal cell microchimerism in papillary thyroid cancer: a possible role in tumor damage and tissue repair

Cirello Valentina , Recalcati Maria Paola , Muzza Marina , Rossi Stefania , Perrino Michela , Beck-Peccoz Paolo , Finelli Palma , Fugazzola Laura

Fetal cells enter the maternal circulation during pregnancy and can persist in the maternal blood or tissues for decades, creating a physiological microchimerism. Since papillary thyroid cancer (PTC) is more frequent in female gender and it is the second more frequent tumor during pregnancy, the role of persisting microchimeric cells has been investigated. Tumour tissue specimens were obtained from 62 women with PTC, 41 of whom had at least one male child before the diagnosis ...

ea0016oc2.6 | Thyroid | ECE2008

Ga-68-Dotatoc PET detects somatostatin receptors in normal thyroids and various thyroid pathologies

Singer Joerg , Lincke Thomas , Sabri Osama , Paschke Ralf

Recent reports confirmed increased SSTR expression in the thyroid in some cases of Graves’ disease and hot nodules. It is still not known, whether SSTRs can frequently be found in other thyroid pathologies or normal thyroid glands. Therefore, we performed a systematic analysis of Ga-68-Dotatoc PET Scans for their thyroid image.Eighty-three consecutive patients undergoing Ga-68-Dotatoc PET were analysed for their relative thyroid uptake by ROI techni...

ea0016oc2.7 | Thyroid | ECE2008

Impact of resistance to thyroid hormone on the cardiovascular system in adult humans

Pulcrano Melania , Mannavola Deborah , Palmieri Emiliano A , Campi Irene , Ciulla Michele , Michi Riccardo , Ippolito Serena , Lombardi Gaetano , Biondi Bernadette , Beck-Peccoz Paolo

Background: Resistance to thyroid hormone (RTH) is an inherited condition of reduced tissue responsiveness to thyroid hormone (TH), biochemically characterized by elevated serum TH concentrations, with inappropriate, non-suppressed thyrotropin levels (TSH). It is caused by point mutations in the ligand binding domain of the TH receptor (TR) β gene, and the mutant TR interferes with the function of the normal TRs (dominant negative effect). The clinical manifestations of R...

ea0016oc2.8 | Thyroid | ECE2008

Graves’ ophthalmopathy in patients treated with radioiodine I-131

Baldys-Waligorska Agata , Buziak-Bereza Monika , Golkowski Filip , Kusnierz-Cabala Beata , Hubalewska-Dydejczyk Alicja , Huszno Bohdan

Introduction: Radioiodine treatment of hyperthyroidism of ophthalmopathy (GO) patients may cause or aggravate GO (in some 15%). We evaluated the activity and severity of ophthalmopathy in patients who acquired GO following radioiodine therapy.Materials and methods: Over the years 2003–2005, 1500 hyperthyroid patients were treated with radioiodine at our Clinic. Of these, 50.9% suffered from Graves’ disease. Following their radioiodine treatment...

ea0016oc2.9 | Thyroid | ECE2008

Subclinical hypothyroidism in older patients: an analysis of natural course and risk factors for the thyroid failure

Djezairi Abdel Hamid

We aimed to evaluate the risk factors for the development of definitive thyroid failure, to analyze the natural course of subclinical hypothyroidism and to quantify the incidence rate of overt hypothyroidism in elderly patients.Two hundred and fourteen patients (186 women and 28 men) over age 60 years with subclinical hypothyroidism and no previous history of thyroid disease were prospectively studied. Subjects were followed up for 6–72 months (mean...