Endocrine Abstracts

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The prevalence of congenital malformations such as hypospadias and cryptorchidism in boys has increased over the past decades, following time trends and geographic distribution of adult reproductive disorders such as testicular cancer and impaired semen quality. This suggests a common prenatal origin of a testicular dysgenesis syndrome. During the first postnatal months, the pituitary–gonadal axis is activated, which can be used as a diagnostic window of testicular functi...

Klinefelter syndrome (KS) is the most common sex chromosome disorder affecting 1:600 men.We know from previous clinical and epidemiological studies that men suffering from KS have an increased risk of diabetes and an increased risk of dying from diabetes, but the reasons for the increased risk are unknown.Seventy KS patients and 71 age-matched men participated in a study on body composition, measures of sex hormones, insulin sensit...

Circumstances of life and food supply have changed in developed countries, resulting in an increasing prevalence of overweight. As a consequence, a complex disorder consisting of visceral obesity, dyslipidemia, insulin resistance and hypertension emerges: the so-called metabolic syndrome leads to the manifestation of diabetes type 2 and cardiovascular disease.In men, testosterone deficiency contributes to the generation of the metabolic syndrome, as demo...