Endocrine Abstracts (2008) 16 P536

The effect of polyunsaturated fatty acids enriched eggs on lipid profile and inflammatory markers

Dana Manda1, Mihaela Giurcaneanu1, Liliana Ionescu1, Rodica Criste2, Tatiana Panaite2, Suzana Vladoiu1, Carmina Busu1 & Olga Ianas1


1C.I. Parhon Institute of Endocrinology, Bucharest, Romania; 2National Research, Development for Biology and Animal Nutrition Institute, Bucharest, Romania.


The correction of a subtle nutritional deficiency that may reduce the risk of a future chronic disease is indeed a challenge. One of the most intriguing current and future impacts on public health may come from a greater intake of omega-3 fatty acids such as α-linolenic acid (ALA).

Objective: We investigated the effect of an increased amount of dietary α-linolenic acid (ALA) from enriched eggs on the lipid profile and inflammatory markers in healthy volunteers.

Subjects and methods: Sixty-two subjects were voluntary enrolled after they gave their informed consent. They were randomly assigned in either control or omega group. Control group consumed normal eggs while omega group consumed eggs enriched in omega 3 fatty acids. The content of ALA in omega 3 eggs was 5 times greater than that of control eggs. During the study, all subjects maintained their habitual diets except that egg consumption. Each subject had to consume 6 eggs a week during a 6-week period.

Blood samples were collected at day 0 (baseline) and at the end of the study.

Triglycerides, cholesterol, HDL, LDL cholesterol, ApoA, ApoB, CRP and fibrinogen were measured in serum samples.

Results: We compared the measured values of the biochemical parameters at baseline and after egg consumption both in control and omega group. Triglycerides were significantly reduced in omega group (P=0.002) after omega-3 enriched eggs consumption but not in control group. Fibrinogen level was significantly decreased (P<0.001) by omega-3 enriched eggs consumption whereas in control group there were no significant changes. No significantly changes were found in the other parameters of the lipid profile or CRP.

Conclusion: Omega-3 dietary supplementation decreases trygliceride and fibrinogen level. Omega-3 enriched eggs can be considered as functional food with beneficial effects on human health.

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