Ghrelin is a pleiotropic hormone characterized mainly by its strong orexigenic action and its role as GH secretagogue.
Age-related level variation of this hormone has been previously shown in different studies centred in mARN expression and in its plasma levels; however there is no data about its secretion directly from the stomach although this is the main ghrelin producing organ.
Objectives: To determine the levels of ghrelin in the postnatal development and its possible sexual dimorfism.
Methods: Real Time PCR, RIA, Organ culture, Surgery.
Experimental groups: Male and female rats from 1 to 24 weeks.
Rats subjected to ovariectomy and orquidectomy.
Results: Our results showed a diminution of ghrelin plasma levels in the second week; levels were normalized in the following weeks. In relation to ghrelin secretion from the stomach, we found a great decrease of secretion in the fourth week and a peak in the sixth week of development.
Gastric ghrelin mARN levels increased along time in a non significant manner. Gonadectomy did not change plasma ghrelin levels although it did affect gastric ghrelin levels.
Conclusions: The weaning and the puberty in the rats regulate gastric ghrelin secretion during postnatal development. Sexual hormones can influence the secretion of ghrelin.
03 - 07 May 2008
European Society of Endocrinology