ECE2008 Poster Presentations Thyroid (146 abstracts)
Analysis of selected adipocytokines in children with autoimmune thyroid diseases
Artur Bossowski 1 , Beata Sawicka 1 , Miroslawa Urban 1 , Marcin Skrzydlo 1 & Mieczyslaw Szalecki 2
12 nd Department of Children’s Disease, Bialystok, Poland; 2The Children’s Memorial Health Institute, Warsaw, Poland.
Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.
The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.
The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and Hashimoto’s thyroiditis (30 girls and 3 boys; aged from 9 to 18- mean 14.5 years). The control group consisted of children with struma nodosa- 11 girls and 2 boys; aged from 9 to 18 -mean 14.6 years. In all patients were performed leptin, adiponectin and resistin levels – ELISA’ method (R&D System, USA).
In children with Graves’ disease we found significantly higher levels of leptin compared to group with Hashimoto’s thyroiditis (12.64 ng/ml vs 7.67 ng/ml, P<0.001). Adiponectin level was higher in children suffering from Graves’ disease compared to group with control and Hashimoto’s thyroiditis (12.33 μg/ml vs 11.7 μg/ml, P<0.05; vs 11.21 μg/ml, P<0.05). Resistin level was higher in group of hypothyroid than hyperthyroid (14.199 ng/ml vs 12.42 ng/ml, P<0.01).
We conclude that thyroid dysfunction plays significant affect on adipocytokine concentrations.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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