Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.
The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves disease and in children with Hashimotos thyroiditis.
The study group formed 78 patients suffering from Graves disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and Hashimotos thyroiditis (30 girls and 3 boys; aged from 9 to 18- mean 14.5 years). The control group consisted of children with struma nodosa- 11 girls and 2 boys; aged from 9 to 18 -mean 14.6 years. In all patients were performed leptin, adiponectin and resistin levels ELISA method (R&D System, USA).
In children with Graves disease we found significantly higher levels of leptin compared to group with Hashimotos thyroiditis (12.64 ng/ml vs 7.67 ng/ml, P<0.001). Adiponectin level was higher in children suffering from Graves disease compared to group with control and Hashimotos thyroiditis (12.33 μg/ml vs 11.7 μg/ml, P<0.05; vs 11.21 μg/ml, P<0.05). Resistin level was higher in group of hypothyroid than hyperthyroid (14.199 ng/ml vs 12.42 ng/ml, P<0.01).
We conclude that thyroid dysfunction plays significant affect on adipocytokine concentrations.
03 - 07 May 2008
European Society of Endocrinology