ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P823

Analysis of selected adipocytokines in children with autoimmune thyroid diseases

Artur Bossowski1, Beata Sawicka1, Miroslawa Urban1, Marcin Skrzydlo1 & Mieczyslaw Szalecki2

12 nd Department of Children’s Disease, Bialystok, Poland; 2The Children’s Memorial Health Institute, Warsaw, Poland.

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.

The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.

The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and Hashimoto’s thyroiditis (30 girls and 3 boys; aged from 9 to 18- mean 14.5 years). The control group consisted of children with struma nodosa- 11 girls and 2 boys; aged from 9 to 18 -mean 14.6 years. In all patients were performed leptin, adiponectin and resistin levels – ELISA’ method (R&D System, USA).

In children with Graves’ disease we found significantly higher levels of leptin compared to group with Hashimoto’s thyroiditis (12.64 ng/ml vs 7.67 ng/ml, P<0.001). Adiponectin level was higher in children suffering from Graves’ disease compared to group with control and Hashimoto’s thyroiditis (12.33 μg/ml vs 11.7 μg/ml, P<0.05; vs 11.21 μg/ml, P<0.05). Resistin level was higher in group of hypothyroid than hyperthyroid (14.199 ng/ml vs 12.42 ng/ml, P<0.01).

We conclude that thyroid dysfunction plays significant affect on adipocytokine concentrations.

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