ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P220

GDM in women younger and older than 28 years: are there any differences in phenotype and biochemical markers?

Sandra Paiva, Luisa Ruas, Jacinta Santos, Elvira Marta, Ermelinda Sobral, António Lobo, Manuela Carvalheiro & Paulo Moura

Coimbra University Hospital, Coimbra, Portugal.

Goal: The aim of this study was to find different characteristics between GDM women aged under (GDM A n=23) and above 28 years (GDM B n=107), followed in our department in 2005.

Material and methods: We performed ANOVA comparisons and computed Pearson correlations/linear regressions between womens’ age and BMI, O’ Sullivan test, OGTT 0 h, 1 h, 2 h and 3 h, new born weight and the need of insulin.

Results: BMI was similar in both groups (mean value A=24.6 kg/m2, B=24.9 kg/m2, P ns). O’Sullivan test measures were significantly higher in group B as compared to group A (mean values B=166 mg/dl, A=151 mg/dl, P=0.04). There was a positive correlation (r=0.272) between these measures and age (P=0.028). We found no significant differences across OGTT measures between these groups. Birth weight was significantly lower in group B compared to group A (mean values B=3.190 kg, A=3.480 kg, P=0.03). Insulin therapy was given more often in group B as compared to group A (35.5% and 8.6% respectively, P=0.011, χ2 test).

Conclusions: Age was not correlated with BMI and OGTT for any of the groups.

The older group had significantly higher levels of O’Sullivan test. Maternal age influenced the need for insulin. In the older group birth weights were lower, probably due to the better glycaemic control, given the more aggressive insulin therapy.

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