ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P374

Pituitary hormone axes in constitutionally tall adolescents

Galina Melnitchenko1, Dmitry Koloda1, Vyacheslav Pronin1, Anatoly Tiulpakov2, Evgeny Gitel1, Zurab Ordzhonikidze3, Vladimir Pavlov3 & Vladimir Preobrazhensky4

1I M Sechenov Moscow Medical Academy, Moscow, Russian Federation; 2Endocrinology Research Center of Federal Agency for Provision of High Technology Medical Aid, Russia, Moscow, Russian Federation; 3Moscow Sports Medicine Research Center, Moscow, Russian Federation; 4Medical Rehabilitation Center of Federal Agency for Public Health and Human Services, Moscow, Russian Federation.

Objective: To evaluate the pituitary hormone axes in adolescents with constitutional tall stature (CTS).

Materials and methods: About 120 patients (54 males and 66 females) with CTS aged 9.6–16.5 years (13.6±2.7 years, mean±S.D.) were enrolled in this study. Sixty-eight normal subjects (24 males and 44 females) aged 9.8–16.2 years (13.1±2.1 years), who were comparable in socioeconomic and nutritional terms, served as controls. Growth hormone, insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), luteinizing hormone, follicle-stimulating hormone and prolactin levels were measured.

Results: In comparison with controls, CTS children showed a slightly lower concentration of IGFBP-3 and a higher concentration of IGF-I but these differences were not significant. In contrast the IGFBP-3/IGF-I molar ratio was significantly lower (0.7±0.1 vs 1.1±0.2; P<0.001) in CTS children than in controls. The concentrations of other pituitary hormone in CTS-affected subjects were not significant different from those determined in controls.

Conclusions: This study has demonstrated that in CTS the most components of pituitary hormone axes are normal, but the IGFBP-3/IGF-I molar ratio is increased, and, therefore, a greater availability of free IGF-I for target tissues may be responsible for overgrowth in CTS.

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