Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All patients were active acromegalic. Diabetic patients were well controlled with diet alone or diet and oral antidiabetic drugs. Diabetic patients were significantly older than nondiabetics(51.94±10.17 vs 41.38±13.43 years, P=0.018). GH and IGF-1 levels were similar in both groups. Visceral adipose tissue content did not differ between diabetic and nondiabetic patients. Age, GH, IGF-1, FBG and fasting insulin were not correlated with adipose tissue content. In conclusion, concomittant well controlled diabetes might not affect visceral fat content in acromegalic patients and this might be at least partly explained by high GH and IGF-1 levels.
03 - 07 May 2008
European Society of Endocrinology