Background: Prolactin hyper secretion is the most common endocrine abnormality due to hypothalamicpituitary disorders. PRL is the hormone most commonly secreted in excess by pituitary adenomas.
Materials and methods: A retrospective study was performed during the period 19982007. The diagnose are based on objective examination, hormonal dosage, MRI.
Results: During these time were diagnosed 98 cases with hyperprolactinemia; 90.8% are females and 9.02% are males. Female/male ratio is 9.8:1.The mean age of diagnosis is 31.8±10.5 years olds.
The diagnosis of a prolactinoma is confirmed by MRI: 35.8% of cases with microadenoma, 32.6% macroadenoma, 1% empty sella syndrome, 30.6% have normal MRI.
The mean value of PRL at the moment of diagnosis was 238±257 ng/ml (N=1.925).
Treatment: Prolactin microadenomas were treated with dopamine agonist drug. About 36.7% were treated with Bromocriptine and 40.8% with Cabergoline.
The mean PRL values before treatment with Cabergoline was 196±16.1 ng/ml, after it 36.9±53 ng/ml. The mean PRL values before treatment with Bromocriptine was 115.8±10.8 ng/ml, after it 51±66 ng/ml.
About 87.5% of macroadenomas underwent surgery due to the complication of pituitary mass. PRL values before surgery was 232±154 ng/ml, after it 162±168 ng/ml.
Because of the still high values of PRL after surgery, drug therapy was used in 59% of them.
Conclusion: The high percentage of macroadenomas is due to the late diagnosis of the cases. All the affected men present pituitary macroadenomas. Drug therapy is more effective than surgery alternative, but treatment should be prolonged.
03 - 07 May 2008
European Society of Endocrinology