Sixty patients with traumatic brain injury are newly diagnosed every year in our island, particularly in patients with addictive behaviours. In France, it is the 4th rank of health expenses, as a major issue of public health care. In order to perform a first endocrine assessment, we performed a pilot study to diagnose traumatic brain injury induced hypopituitarism, assessed at least 6 months after injury, in moderate to severe traumatic brain injuries patients, hospitalized in our institution, from July 2005 to July 2006. It was a transversal study, approved by the Ethics Committee System of Bordeaux. All patients gave their informed consent after oral and written information. Over 65 medical files, 36 met our criteria: 12 patients died (6 in intensive care unit and 6 after their discharge); 14 out of 24 survivors were excluded after the first appointment (7 patients declined; 7 were lost for follow up). Of the 10 remaining patients, 6 showed traumatic brain injury hypopituitarism: 3 isolated growth hormone deficiencies (2 severe, 1 partial), 2 adrenocorticotropic hormone deficiencies associated with 1 partial and 1 severe growth hormone deficiency and 1 isolated thyroid stimulating hormone deficiency. This study pointed out the different difficulties we also met. This pilot study will lead to a further multicentric long-term study, in order to perform statistical analysis and to compare our results to those of the literature.