It was postulated that different therapeutic approaches could influence the markers of inflammation in obesity but it is unknown whether overweight women with and without metabolic syndrome have the same degrees of inflammatory state. The aim of our study was to compare level of hs-CRP in obese women without other components of metabolic syndrome with hs-CRP in women with metabolic syndrome (according IDF criteria). Overweight body mass index-matched women without (OW)) (n=16, (body mass index, 35.56±0.09 kg/m2) and with (May (n=13) metabolic syndrome (body mass index, 6.76±1.57 kg/m2) were included in the study. C-reactive protein (CRP) between groups was not significantly different (4.39±0.711 mg/liter for OW vs 6.02±1.55 mg/l for MSy, P>0.05). There was a significant difference in triglyceride levels (1.12±0.14 for OW vs 2.86±0.46 mmol/l for MSy, P<0.05, HDL-cholesterol (1.35±0.06 for OW vs 1.13±0.05mmol/l for MSy, P<0.05), waist circumference (102.6±2.82 cm for OW vs 112.31±3.03 cm for MSy, P<0.05), but not in HOMA-IR index (3.86±0.40 for OW vs 4.46±0.96 for Msy, P>0.05). There was no significant correlation between CRP and BMI neither between CRP and HOMA-IR. Our results couldnt confirm higher degree of insulin resistance between severe obese women with and without other component of metabolic syndrome as well as difference in CRP levels.