Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.
Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovary syndrome.
Methods: The study group consisted of 15 normal weight young women with PCOS (BMI 23.4±4.8 kg/m2, age 25.1±5.4) and 10 healthy controls (BMI 20.7±1.5 kg/m2, age 26.8±6.5). A complet hormonal assay was performed in each subject. Serum glucose, basal insuline levels, holesterol, HDL, LDL, and triglyceride were measured. Arterial structure was evaluated by intima-media tickness (IMT) of carotid artery which is a morphological marker of precocious atherosclerosis. Longitudinal ultrasonografic scan of the carotid arteries were performed by expirienced ultrasonographer who was blinded to clinical data. IMT was measured from the B-mode screen by 7.5 MHz linear probe of both common carotid arteries. Statistical analyse was done by ANCOVA using cholesterol, HDL, LDL, triglyceride and baseline insulin level as covariable (separatly).
Results: We found statisticaly significant difference between IMT in PCOS women (0.51±0.06 mm) versus healthy controls (0.42±0.03 mm). Only PCOS effect was significant.
Conclusions: In this group of patients, differences in IMT seems to be atributable to PCOS facors other than insulin, cholesterol and trigyceride levels.
03 - 07 May 2008
European Society of Endocrinology