To asses the presence of antibodies to BIP/GRP78, which is a chaperon of endoplasmic reticulum and has immune modulating and antiapoptotic effects in Hashimotos thyroiditis.
The study included 62 patients with autoimmune thyroiditis. Of these, 20 had euthyroid, 27 had subclinical hypothyroid, and 15 had hypothyroid Hashimatos thyroiditis. A control group including 37 healthy patients also participated in the study.
There was no statistically significant difference between subgroups of Hashimotos thyroiditis patients and control group, and between subgroups of Hashimotos thyroiditis patients, individually; when comparison was made in respect of Anti-BIP levels (P=0.889).
Although BIP activation has previously been shown, the Anti-BIP level was not different from the control group in subgroups of Hashimotos thyroiditis patients in our study. This condition suggests that antibodies formed aganist BIP by apoptosis and/or T cell response are not associated with Hashimotos thyroiditis or that it is at a level in serum that can not be measured.
03 - 07 May 2008
European Society of Endocrinology