Endocrine Abstracts (2008) 16 P684

Anti-BIP levels on Hashimoto's thyroiditis

Mehmet Asik, Mustafa Sahin, Serap Arikan, Alptekin Gursoy, Semra Ayturk, Okan Bakiner & Neslihan Bascil Tutuncu


Baskent University, Ankara, Turkey.


To asses the presence of antibodies to BIP/GRP78, which is a chaperon of endoplasmic reticulum and has immune modulating and antiapoptotic effects in Hashimoto’s thyroiditis.

The study included 62 patients with autoimmune thyroiditis. Of these, 20 had euthyroid, 27 had subclinical hypothyroid, and 15 had hypothyroid Hashimato’s thyroiditis. A control group including 37 healthy patients also participated in the study.

There was no statistically significant difference between subgroups of Hashimoto’s thyroiditis patients and control group, and between subgroups of Hashimoto’s thyroiditis patients, individually; when comparison was made in respect of Anti-BIP levels (P=0.889).

Although BIP activation has previously been shown, the Anti-BIP level was not different from the control group in subgroups of Hashimoto’s thyroiditis patients in our study. This condition suggests that antibodies formed aganist BIP by apoptosis and/or T cell response are not associated with Hashimoto’s thyroiditis or that it is at a level in serum that can not be measured.

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