ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P719

Alterations of the circulating selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in patients with non-immune nodular thyroid disease

Kristine Ducena1,2, Peteris Tretjakovs1,2, Antra Jurka1,2, Inga Bormane1,2 & Valdis Pirags1,2

1University of Latvia, Riga, Latvia; 2Pauls Stradins Clinical University Hospital, Riga, Latvia.

Cytokines, including adhesion molecules, are a family of protein mediators that are important in transducing information between various cell types, were non-immune cells may also be important sources of certain cytokines.

Aim: Aim of this study was to evaluate of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) in patients with non-immune nodular thyroid disease.

Materials and methods: We formed two study groups: 32 patients with non-toxic, non-immune nodular thyroid disease (P) and 32 healthy subjects were selected as controls (C). The histological examination revealed follicular adenomas in all of the cases. All patients were without autoimmune diseases, cancer and coronary heart disease. The study groups were matched for age, sex, and body mass index. sICAM-1, sVCAM-1 and sE-selectin were measured by xMAP technology (Luminex-200 analyzer).

Results: sICAM-1, sVCAM-1 and sE-selectin levels were statistically significantly elevated in patient group compared to healthy subjects (P versus C, P<0.05).

Conclusion: Our findings show that patients with non-immune nodular thyroid disease have significantly elevated sICAM-1, sVCAM-1 and sE-selectin levels.

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