The aim of the study was to assess the influence of thyroid hormones on lipid profiles in primary hypothyroidism, in order to determine the most influential one for the clinical follow-up. Study group included 15 subjects (3 male, 12 female, age 46±13 years/mean±S.D.), and total and free T4, total and free T3 and TSH, total, HDL and LDL cholesterol, triglycerides, ApoA, ApoB and Lp(a) were determined. The diagnosis of primary hypothyroidism was based on increased TSH and decreased FT4 concentrations. We found that only FT3 was inversely correlated with total cholesterol, triglycerides and ApoB concentrations. Other assessed hormones were not significantly correlated with any of the measured parameters. Therefore, FT3 should be assessed in patients with patients with primary hypothyroidism and lipid disorders.
03 - 07 May 2008
European Society of Endocrinology