ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2008) 16 P736

Evolution of thyroid autonomy in iodine sufficient environment

Josip Zmire, Kresimir Martinac, Kristijan Peros, Kristina Kljajic, Bozo Colak & Lea Sokolic

Vuk Vrhovac University Clinic, Zagreb, Croatia.

Last 10 years, we are living in iodine sufficient environment. To clarify natural course of thyroid autonomy in this conditions, we investigated 100 consecutive patients in last three months – 93 female and 7 male aged 19–86 years. Included were patients with scans showing thyroid autonomy, and patients with nodular or diffuse goiter with low or suppressed TSH. We followed them from their first visit. Thirty patients were hyperthyroid – one spontaneously cured, 50 had low or suppressed TSH, and 20 had normal both TSH and thyroid hormones. Twenty-five patients presented with mild hyperthyroidism from the very beginning, in 5 patients hyperthyroidisnm developed in next 1–5 years. In two patients, thyroid autonomy developed after cure od autoimmune hyperthyroidism. One patient had papillary thyroid carcinoma and hyperthyroidism in nodular goiter. Considering the fact that hyperthyroid patients have at least one visit in 3–4 months, that those with low TSH, we follow twice a year, and that those with normal hormones, we see once a year, we approximate that 18% of our patients with thyroid autonomy are hyperthyroid.

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