Introduction: Serum thyroglobulin (Tg) measurement is the marker of differentiated thyroid carcinoma (DTC) after total thyroidectomy, but its value is limited by the interference of anti-Tg antibodies (TgAb). Detection of Tg in fine-needle aspiration biopsy (TG-FNAB) washout fluid is used recently to identify neck DTC metastases, but the interference of TGAb-FNAB in the procedure is unknown.
Objectives: To evaluate the utility of TG-FNAB for detecting cervical lymph node metastases from DTC. To evaluate the presence of anti-Tg antibodies in this fluid.
Patients and methods: An ultrasound-FNAB was done in all patients with suspected recurrence or metastasis of CDT treated at the Alicante General University Hospital since June 2006 since November 2007. Tg and TgAb serum and liquid-FNAB was assayed by chemiluminescent assays (IMMULITE 2000, Siemens©). The aspirated material was cytologicaly examined and were reported by an experienced cytologist.
Conclusions: Tg-FANB could be a marker in the early diagnosis of DTC recurrent or metastatic. The clinical performance of Tg-FANB fluid appears to be not affected by TgAb-FANB, on the observed data.
|FANB washout fluid||Serum|
|Tg (ng/ml)||TgAb (UI/ml)||Tg (ng/ml)||TgAb (UI/ml)||Cytology|
|Group 1 n=4||3392||<5||<0.2||<5||Metastatic DTC|
|21 460||<5||1.1||<5||Metastatic DTC|
|Group 2 n=4||<0.2||<5||<0.2||6.2||No malignancy|
|Group 3 n=2||<0.2||<5||0.3||13.1||Inadequate|
|Group 4 n=2||0.7||<5||18.1||9.3||No malignancy|
03 - 07 May 2008
European Society of Endocrinology