Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2008) 16 P802

ECE2008 Poster Presentations Thyroid (146 abstracts)

Serum thyrotropin concentration as a biochemical predictor of thyroid malignancy in patients presenting with thyroid nodules

Stergios Polyzos 1 , Marina Kita 1 , Zoe Efstathiadou 1 , Pavlos Poulakos 1 , Aristidis Slavakis 2 , Danae Sofianou 2 , Nikolaos Flaris 3 , Maria Leontsini 3 , Anargyros Kourtis 1 & Avraam Avramidis 1

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1Department of Endocrinology, Hippokratio General Hospital, Thessaloniki, Greece; 2Department of Microbiology, Hippokratio General Hospital, Thessaloniki, Greece; 3Department of Pathology, Hippokratio General Hospital, Thessaloniki, Greece.


Background: Fine-needle aspiration biopsy is the ‘gold standard’ in the preoperative management of thyroid nodules.

Aim: The aim of this study was to investigate whether serum TSH is a predictor of thyroid malignancy in patients presenting with thyroid nodules.

Subjects and methods: About 565 patients without overt thyroid dysfunction, who presented with palpable thyroid nodule(s) between 1988 and 2004 and underwent at least one FNAB, were retrospectively evaluated.

Results: The final diagnostic outcome was established after surgery (n=122) or after a minimum of one-year clinical follow-up period. Higher rates of malignancy were observed in patients with serum TSH in the upper tertile of the normal range (P=0.026). Binary logistic regression analysis revealed significantly increased adjusted odds ratios for the diagnosis of malignancy in patients with serum TSH 1.5–4.0 mIU/l compared to those with either TSH 0.4–0.8 mIU/l (P=0.005) or TSH 0.9–1.4 mIU/l (P=0.007).

Conclusions: The risk of malignancy in thyroid nodules increases in parallel with TSH concentrations within the normal range. TSH concentration at presentation is an independent predictor of thyroid malignancy.

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