It was previously shown that patients with primary hyperparathyroidism (PHPT) are insulin resistant. The aim of our study was to evaluate the effect of surgical treatment on insulin sensitivity and lipid levels in patients with PHPT. In 21 patients with PHPT (age: 56.24±8.69 years, BMI 25.2±3.81 kg/m2) lipid levels (TC, HDL, LDL, TG, Lp(a)) and insulin sensitivity were determinated before and 4 months after surgical treatment. Insulin sensitivity was evaluated using euglycemic hyperinsulinemic clamp.
Results: There was significant difference in insulin sensitivity (M index: 4.07±2.05 vs 7.14±4.91, P<0.01) before and after surgical treatment, while there was no change in BMI before and after testing (25.20±3.81 vs 25.39±3.56, P>0.05). There was no difference in TC (6.07±1.45 vs 5.97±1.35, P>0.05), HDL (1.23±0.35 vs. 1.25±0.36, P>0.05), LDL (3.85±1.18 vs 3.93±1.26, P>0.05), Lp(a) (0.21±0.27 vs 0.18±0.22, P>0.05) and TG (1.87±0.81 vs 2.16±1.03, P>0.05) levels before and after surgical treatment. In conclusion, radical treatment improves insulin sensitivity in patients with PHPT.