Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2009

Clinical Management Workshops

Improving mortality and morbidity in pituitary disease

ea0019s50 | Improving mortality and morbidity in pituitary disease | SFEBES2009

Mortality in patients with pituitary disease

Newell-Price John

Following seminal observations published nearly 20 years ago, it is apparent, increasingly, that patients with pituitary disease have excess mortality due to cardiovascular, cerebrovascular and respiratory causes; with women having a worse outcome than men. Patients with craniopharygioma have the greatest risk. There does not appear to be an overall excess of death due to malignancy. Despite large retrospective and prospective database cohort analyses, the precise reasons for ...

ea0019s51 | Improving mortality and morbidity in pituitary disease | SFEBES2009

Does hormone replacement normalise life expectancy?

Drake William

Several reports indicate that hypopituitarism is associated with decreased life expectancy compared to age-matched healthy controls and that this mortality penalty exists despite ‘adequate’ or ‘satisfactory’ replacement with glucocorticoids, thyroid hormone and sex steroids. Almost coincident with these studies came a series of randomised, placebo-controlled trials, in which it was convincingly demonstrated that treatment of growth hormone deficient (GHD) a...

ea0019s52 | Improving mortality and morbidity in pituitary disease | SFEBES2009

Why craniopharyngioma remains a condition with a high mortality and morbidity?

Karavitaki Niki

Craniopharyngiomas are rare, sellar/parasellar tumours diagnosed during childhood or adult life.Despite their benign histological appearance, they are associated with substantial morbidity (endocrine, visual, hypothalamic, as well as neurobehavioural and cognitive) compromising psychosocial integration, quality of life and survival. These complications are the result of the damage by the primary (they tend to be large lesions, most of which with signific...

ea0019s53 | Improving mortality and morbidity in pituitary disease | SFEBES2009

Adverse outcomes following pituitary radiotherapy

Ayuk J

External beam radiotherapy has been used in the management of hormonally active and non-functioning pituitary adenomas for nearly a century. Administered postoperatively, radiotherapy significantly reduces the likelihood of tumour re-growth following surgery for non-functioning pituitary adenomas. In patients with acromegaly, Cushing’s disease and resistant prolactinomas, conventional fractionated radiotherapy suppresses functional hypersecretion. However, over the years,...