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11th European Congress of Endocrinology

Oral Communications

Diabetes & Obesity

ea0020oc2.1 | Diabetes & Obesity | ECE2009

ESE Young Investigator Award

Dirice Ercument , Sanlioglu Ahter Dilsad , Kahraman Sevim , Omer Abdulkadir , Balci Mustafa Kemal , Griffith Thomas S , Sanlioglu Salih

Background: Because type 1 diabetes (T1D) results from the T cell-mediated destruction of the insulin-producing pancreatic beta cells, the depletion of the autoreactive T cells via apoptosis represents a viable strategy for the prevention of autoimmune diabetes. The functional role TNF Related Apoptosis Inducing Ligand (TRAIL), a novel member of TNF superfamily, in autoimmune diabetes remains unknown. To understand this, TRAIL function was counteracted by an injection of solub...

ea0020oc2.2 | Diabetes & Obesity | ECE2009

Thymocyte migration is impaired in NOD mice: combined role of extracellular matrix and chemokines

Mendes-da-Cruz Daniella , Bauer Moises , Smaniotto Salete , Keller Alexandre , Savino Wilson , Dardenne Mireille

The NOD (non-obese diabetic) mouse remains the best experimental model of type I diabetes. We have previously described several thymic dysfunctions in these animals, including the presence of giant perivascular spaces (PVS) with arrest of mature T cells (including Treg cells) and partial impairment on fibronectin/VLA-5-dependent NOD thymocyte migration. Herein, we further studied the role of extracellular matrix (ECM) ligands, alone or in combination with the chemokine CXCL12 ...

ea0020oc2.3 | Diabetes & Obesity | ECE2009

Central ghrelin administration reduces starvation-induced inflammation in rats

Stevanovic Darko , Trajkovic Vladimir , Nesic Dejan , Micic Dragan , Sumarac-Dumanovic Mirjana , Popovic Vera , Starcevic Vesna

The aim of the study was to investigate the influence of intracerebroventricular (ICV) injections of ghrelin on secretion of pro-inflammatory (TNF, IL-1, IFN-γ) and anti-inflammatory cytokines (TGF-β) in starved rats. Male Wistar rats (4 weeks old, 12 per group) were fed ad libitum or starved by caloric restriction (40% of chow consumed by their ad libitum fed controls from previous day) for 4 weeks. Afterwards, half of the animals in each group receive...

ea0020oc2.4 | Diabetes & Obesity | ECE2009

Mc2 receptor in adipocytes is significant for lipid composition and regular lipolysis

Hatiboglu Nilay , Betz Matthias J , Hadaschick Dirk , Mauracher Brigitte , Rachl Monika , Demmelmair Johann , Koletzko Berthold , Slawik Marc , Beuschlein Felix

The melanocortin system is significant for energy homeostasis and receptors have distinct tissue specific expression. The melanocortin 2-receptor (Mc2r) transmits ACTH dependent signalling in the adrenal cortex. Increased expression in adipocytes during differentiation indicates relevance for lipid homeostasis. Mc2r activation in adipocytes results in increased lipolysis, however, implication compared to norepinephrine (NE) stimulated lipolysis is unknown. To further define fu...

ea0020oc2.5 | Diabetes & Obesity | ECE2009

Regular aerobic activity attenuates caspase-3 activity, oxidative stress, and progression of diabetic nephropathy in db/db mice, independent of hyperglycemia

Ghosh Sanjoy , Verchere Bruce , Laher Ismail

Diabetic nephropathy, the leading cause of end-stage renal disease, is characterized by a pro-apoptotic and pro-oxidative environment. The mechanisms by which lifestyle interventions, such as exercise, benefits diabetic nephropathy are unknown. We hypothesized that exercise inhibits early diabetic nephropathy via attenuation of the mitochondrial apoptotic pathway and oxidative damage. Type 2 diabetic db/db and normoglycemic wild type mice were exercised for an hour ever...