Searchable abstracts of presentations at key conferences in endocrinology
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11th European Congress of Endocrinology

Oral Communications

Endocrine Tumours

ea0020oc1.1 | Endocrine Tumours | ECE2009

Optimizing time of prophylactic surgery in ret gene carriers on the basis of serum calcitonin

Elisei Rossella , Romei Cristina , Bottici Valeria , Cosci Barbara , Renzini Guilia , Molinaro Eleonora , Agate Laura , Pinchera Aldo

Multiple endocrine neoplasia type 2 (MEN 2) is characterized by the presence of medullary thyroid cancer (MTC) and other benign pathologies. RET mutations are responsible of this disease and their screening is a very sensitive tool for the identification of gene carriers (GC).Aim of this study was to verify the relevance of the basal and pentagastrin (Pg) stimulated serum calcitonin (CT) in the decision to perform TT in GC. We reviewed data of 65 GC foun...

ea0020oc1.2 | Endocrine Tumours | ECE2009

Long-term outcome of laparoscopic versus open adrenalectomy for adrenocortical carcinoma

Fassnacht Martin , Brix David , Fenske Wiebke , Langer Peter , Nies Christoph , Agha Ayman , Beuschlein Felix , Johanssen Sarah , Riedmiller Hubertus , Allolio Bruno

Introduction: Surgery is the established first line treatment in adrenocortical carcinoma (ACC). For benign adrenal tumours, laparoscopic adrenalectomy (LA) has become the treatment of choice. However, the role of LA in ACC remains highly controversial. Data from the German ACC Registry were used to evaluate the technical feasibility of LA in ACC and to compare the long-term outcome after LA with the results of open adrenalectomy (OA).Methods: Out of 521...

ea0020oc1.3 | Endocrine Tumours | ECE2009

131I-Iodometomidate radiotherapy for metastatic adrenocortical carcinoma: first clinical experience

Hahner Stefanie , Kreissl Michael , Fassnacht Martin , Johanssen Sarah , Haenscheid Heribert , Reiners Christoph , Allolio Bruno , Schirbel Andreas

Subject: Treatment options for adrenocortical carcinoma (ACC) are still unsatisfactory. We could recently demonstrate that several patients with ACC exhibit a high and specific uptake of 123I-Iodometomidate (123I-IMTO). Therefore, we investigated if 131I-IMTO holds potential for radiotherapy in ACC.Methods: Dosimetry with 40 MBq I-131-IMTO was performed over 5 days in 7 patients and calculated activities were administered on a compassionate use basis in ...

ea0020oc1.4 | Endocrine Tumours | ECE2009

ESE Young Investigator Award

Tombol Zsofia , Szabo Peter M , Molnar Viktor , Wiener Zoltan , Horanyi Janos , Riesz Peter , Liko Istvan , Patocs Attila , Gaillard Rolf-Christian , Falus Andras , Racz Karoly , Igaz Peter

Introduction: MicroRNAs (miRNA) are non-coding RNA molecules involved in the posttranscriptional regulation of gene expression. MiRNAs bind mRNA molecules at their 3′ untranslated regions and induce translational repression or target degradation. MiRNAs play important roles in the pathogenesis of several neoplasms. There are no reports, however, on the possible involvement of miRNAs in the pathogenesis of adrenocortical tumors.Objective: To study s...

ea0020oc1.5 | Endocrine Tumours | ECE2009

Bone morphogenetic protein 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

Johnsen Inga , Kappler Roland , Auernhammer Christoph , Beuschlein Felix

Bone morphogenetic proteins (BMPs) have been demonstrated to impact tumorigenesis in a variety of tumors. As for the adrenal cortex, quantitative real time PCR analyses revealed down-regulation of various BMPs (e.g. BMP2, BMP5) in tissue samples from adrenocortical carcinoma and adrenocortical tumor cell lines in comparison to normal adrenal glands. Other members, by contrast, as seen for BMP6 remained unaltered. Integrity of BMP dependent pathways in the investigated cell lin...

ea0020oc1.6 | Endocrine Tumours | ECE2009

Implication of the Wnt/β-catenin signaling pathway activation in the adenoma and in the malignant adrenocortical cancer

Czarnocka Barbara , Kasperlik-Zaluska Anna , Bardadin Krzysztof , Roszkowska Katarzyna , Cichocki Andrzej

The commonly expressed multifunctional protein and protooncogene β-catenin displays important functions in cell–cell adhesion and in the Wnt signaling pathway. Transforming activity of the Wnt/β-catenin pathway is thought to be involved in the development of a variety of human cancers and many β-catenin target genes have been shown to play critical functions in tumors. Therefore, the aim of this project was to determine the expression levels and cellular di...