Background: Hashimotos thyroiditis is a chronic autoimmune thyroiditis. It is the most common cause of primary hypothyroidism in adolescent period, via autoimmune thyroid tissue destruction and affecting 2% of the population. In this study we want to investigate the role of the cytokines such as IL-2, IL-12, TNF-α and IFN-γ in the pathogenesis of the disease and the changes of cytokine levels with the L-thyroxine treatment.
Methods: About 65 female patients, aged 1873 years with Hashimotos thyroiditis referred to Celal Bayar University Medical Faculty Endocrinology polyclinic were included in this study. After a 1012 weeks L-thyroxin therapy period, all of the patients were turn into euthyroidic state. There was a statistically significant decrease in the levels of TSH (P<0.0001) and increase in the levels of FT4 (P<0.0001) at the same time. Also, the levels of anti-Tg (P<0.01) and anti-TPO (P<0.001) were significantly lower than pre-trreatment period. After the L-thyroxine treatment, a statistically significant decrease was shown (P<0.001) for the IL-12 levels. But decreasing of the IFN-γ levels was not statistically significant (P=0.276). On the other hand, no changes were determined of the IL-2 and IL-4 levels.
Conclusion: In our study which took a 1012 week treatment (therapy) period, although there was a statistically significant decrease in serum IL-12 level, the statistically insignificant decrease in IFN-γ level can be interpreted as the inflammatory process in Th 1 type was stopped or slowed down.
25 - 29 Apr 2009
European Society of Endocrinology