Endocrine Abstracts

Background: Anemia is a common problem in diabetic patients. Diabetic patients have a greater degree and severity of anemia for their level of renal impairment compared to non-diabetic patients. This study examines the prevalence of anemia in type 2 diabetic patients and to determine the contribution roles of different stages of nephropathy in development of anemia in this patient.

Methods and materials: Of 1962 outpatients type 2 diabetes were selected. A full blood count, iron indices were obtained from all patients. The prevalence and correlation of anemia with other variables identified with multivariate logistic regression.

Results: Of 9.2% of male and 10.4% of female patients had anemia. Prevalence of elevated albuminuria (micro or macroalbuminuria) was 38.1%. Of 8.1% of our patients had moderate (creatinine clearance <60 ml/min per 1.73 m²) and 31.4% had mild (CCr=60–90) renal impairment. Patients with moderate renal impairment had significant more anemia than patients with mild renal failure (30 vs 9%, P=0.000). Patients with diabetes and macroalbuminuria were also likely to have more anemia than patients with microalbuminuria (32.4 vs 8.4%, P=0.000). Also patients with microalbuminuria were more likely to have anemia than patients without elevated albuminuria (8.4 vs 5.7%, P=0.000). Cardiovascular disease and retinopathy were more in diabetic patients with anemia than patients without anemia (P=0.01, 0.001 respectively).

Conclusion: Anemia is a high prevalent finding in type 2 diabetic patients. Any degree of renal impairment and albuminuria are greatest risk factors for anemia in this patients.