Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2009) 20 P445

ECE2009 Poster Presentations Obesity and Metabolism (70 abstracts)

Effect of metformine treatment on serum paraoxonase and oxidative status in obese women

Semin Fenkci 1 , Nedim Karagenc 2 & Fulya Akin 3

1Department of Internal Medicine, School of Medicine, Pamukkale University, Denizli, Turkey; 2Department of Medical Biology, School of Medicine, Pamukkale University, Denizli, Turkey; 3Department of Endocrinology and Metabolism, School of Medicine, Pamukkale University, Denizli, Turkey.

Objective: To evaluate the effects of metformine newly using in clinical practice to ameliorate insulin resistance on paraoxonase activity and oxidative stress in obese insulin resistant women.

Materials and methods: Sixty-seven obese (BMI≥30 kg/m2) women were enrolled into this study. Serum fasting (F.Glc) and postprandial glucose (P.Glc), insulin, uric acid (UA), paraoxonase (PON1), Arylesterase (AET), malondialdehyde (MDA), cupper-MDA (Cu-MDA) levels and lipid fractions were measured at the commencement and ending of the study. Homeostasis model assessment (HOMA-R) was used to estimate insulin resistance. HOMA-R ≥ 2.7 levels were accepted as positive insulin resistance. According to this proposal, insulin resistant (IR+) 32 women were defined as Group I and no insulin resistant (IR−) 35 as Group II. Cases in Group I were managed by diet + exercise + metformine (1700 mg/d), cases in Group II were only treated by diet + exercise for 6-month interval. Intra and inter alterations of all parameters were statistically calculated.

Results: Basal PON1, MDA, Cu-MDA and HOMA-R values were considerably higher in Group II than those in Group II. Reduced PON1/AET ratio, HOMA-R, HDL and PON1 values were observed in Group I. The increases in AET/HDL and Cu-MDA were significant. While increases in LDL, Cu-MDA, AET/HDL and HOMA-R values were observed, HDL level reduced in Group II. Decreases in HOMA-R values were further in Group I than in Group II. But increases in Cu-MDA levels were significantly higher in Group II compared to those in Group I.

Conclusions: We thought that metformine treatment with intensive life-style changing is appropriate management in obese, insulin resistant women who have increased propensity for the development of Type 2 DM.

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