Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2009) 20 P473

ECE2009 Poster Presentations Obesity and Metabolism (70 abstracts)

Association between platelet count and metabolic risk factors in over weight and obese women

Faruk Kutluturk 1 , Sinan Tanyolac 2 , Adil Azezli 2 & Yusuf Orhan 2

1Division of Endocrinology and Metabolism, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey; 2Division of Endocrinology and Metabolism, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Introduction: We aimed to evaluate the relationship between platelet count and metabolic risk factors in over weight and obese women in Turkish women.

Methods: Over weight (BMI>25 kg/m2) 665 and obese (BMI>30 kg/m2) 4609 women were enrolled into the study. The patients were divided into three group according to the platelet count (PLT), Group I (n=1724) consist of serum PLT≤245×103, group II (n=1787) consist of PLT 245×103 to 300×103 and, group III (n=1763) consist of PLT >300×103 μl. The groups were compared for metabolic risk markers.

Results: Body weight, BMI and body fat mass, waist circumference, sagital waist, fasting glucose, insulin, HOMA, A1c, total cholesterol, LDL-cholesterol, triglycerides, hs-CRP, ESR and, systolic and diastolic blood pressures were significantly high in Group III compared to Group I and Group II (P<0.05).

Table The comparison of different platelet (PLT) groups.
Group I (n=1724)Group II (n=1787)Group III (n=1763)P value
Age (years)40.88±12.7540.18±12.1939.17±11.870.003
Weight (kg)84.99±18.3187.57±17.8791.20±19.38<0.001
BMI (kg/m2)34.06±7.5635.14±7.2336.65±7.69<0.001
Waist circumference (cm)96.72±14.9899.05±14.35102.05±20.64<0.001
Saggital waist (cm)23.61±4.1124.49±4.4225.50±4.29<0.001
Glucose (mg/dl)97.67±26.9397.52±24.1199.80±31.440.241
HbA1C (%)5.74±0.885.78±0.815.85±1.050.361
Insulin (uIU/ml log)12.45±12.0012.98±9.7215.20±13.49<0.001
HOMA (log)3.11±4.113.20±2.823.94±5.48<0.001
LDL-kol (mg/dl)123.38±38.64127.79±37.91128.94±39.040.001
Triglicerides (mg/dl log)137.13±110.95143.68±124.63151.20±105.280.015
Systolic DB (mmHg)126.83±24.86127.55±23.30130.89±23.51<0.001
Diastolic DB (mmHg)80.97±13.5581.51±13.5982.91±14.47<0.001

Conclusion: The data obtained from this study indicates that high PLT count is associated with several metabolic risk markers. Platelet count can be suggested as a risk marker for atherosclerotic disease in overweight and obese women.

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