Objective: Acromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence of colonic polyps in acromegalic subjects, and also whether there is a relationship between insulin-like growth factor 1 (IGF-1), growth hormon (GH), fasting insulin plasma levels and the presence of polyps.
Material and methods: Fifty-four consecutive acromegalic patients and 45 IBS patients were enrolled to study between 2004 and 2008. Groups including acromegalic patients and controls were age and sex matched. All patients underwent colonoscopy and received a histological diagnosis of colorectal lesions. Serum GH, IGF-1, insulin levels were compared between acromegalic patients with and without colorectal lesion.
Results: Acromegalic patients mean age was 44±10.9 years (20 males and 34 females, mean duration of disease 53.5±47.6 months) and IBS patients mean age was 47±11.1 years (15 males and 30 females). 14 of 54 cases (25.9%) had colonic polyps. Eight (57.1%) had hyperplastic polyps, 5 (35.7%) had adenomatous polyps, and 1 (7.1%) had leomyoma. In the IBS group, 4 (8.8%) had colonic polyps; all polyps were hyperplastic. The prevalence of hyperplastic and adenomatous polyps were significantly higher in acromegalic patients (P=0.02). The group of acromegalic patients with and without polyps did not differ significantly in duration of disease, body mass index, plasma GH, IGF-1, fasting insulin levels and glycemic status (Impaired glucose tolerance, impaired fasting glucose and diabetes mellitus). The presence of colonic polyps was correlated with patients age (P=0.009) and male gender (P=0.01).
Conclusion: Acromegalic patients have a higher prevalence of colonic polyps than IBS subjects. There was no correlation between IGF-1, GH, fasting insulin plasma levels, glycemic status, HOMA-IR and colonic polyps in acromegalic patients.
25 - 29 Apr 2009
European Society of Endocrinology