Polycystic ovary syndrome (PCOS) is associated with adiposity and metabolic changes predisposing to insulin resistance. Because the recently discovered GH secretagogue, ghrelin is intimately involved in the control of appetite and weight regulation, we investigate ghrelin levels in non-obese and obese PCOS patients. Ten obese (BMI=32.50±1.57 kg/m2) and ten non-obese (BMI=20.45±0.51 kg/m2) patients with PCOS and their respective controls were evaluated. Fasting ghrelin was significantly lower in non-obese PCOS (51.82±26.83; P<0.05) as well as in obese PCOS (42.65±26.91; P<0.05) in comparison with controls (non-obese controls 120.11±58.42; obese-controls 96.33±37.34; P<0.05) matched for age and body mass index. In conclusion, women with PCOS had lower fasting ghrelin independently of their BMI, compared to the controls and there were no differences between fasting ghrelin levels among non-obese and obese women with PCOS. The ghrelin level in women with PCOS reflects the metabolic and hormonal changes which are characteristics of the syndrome.