Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 21 | SFEBES2009 | Next issue

Society for Endocrinology BES 2010

Oral Communications

Neuroendocrine tumours/pituitary

ea0021oc2.1 | Neuroendocrine tumours/pituitary | SFEBES2009

A novel mechanism of effect for somatostatin analogues: the role of AIP

Chahal Harvinder , Alband Neda , Ansorge Olaf , Karavitaki Niki , Carlsen Eivind , Wass John , Grossman Ashley , Korbonits Marta

Background: Recently, germline mutations in the aryl-hydrocarbon-receptor-interacting-protein (AIP) gene have been found to occur in familial and sometimes in early onset sporadic somatotroph adenomas. These tumours tend to respond less well to somatostatin analogues (SSA). It has been shown previously that AIP can upregulate the transcription factor Zac1 in liver cells, and we were able to also demonstrate this in pituitary cells. On the other hand, Zac1 is upregulated in res...

ea0021oc2.2 | Neuroendocrine tumours/pituitary | SFEBES2009

Wnt/β-catenin signalling is down-regulated in pituitary tumours from a multiple endocrine neoplasia type 1 (MEN1) mouse model

Walls Gerard , Newey Paul , Nesbit M Andrew , Jeyabalan Jeshmi , Schulz Herbert , Huebner Norbert , Thakker Rajesh

The tumour suppressor menin, encoded by the multiple endocrine neoplasia type 1 (MEN1) gene, has been reported to be a component of the Wnt/β-catenin signalling pathway. To investigate the effects of menin loss on this pathway, we have determined the cDNA expression profiles of pituitary tumours from 5 Men1+/− mice and in normal pituitaries from 5 Men1+/+ littermates by extracting total RNA and by hybridizing it to Affymetrix Mous...

ea0021oc2.3 | Neuroendocrine tumours/pituitary | SFEBES2009

11C-Metomidate positron emission tomography (PET) scanning for Conn's syndrome

Burton Timothy , Annamalai Anand , Bird Nick , Gurnell Mark , Brown Morris

Primary hyperaldosteronism usually results from an aldosterone-secreting adenoma of the adrenal cortex (Conn’s adenoma) or bilateral adrenal hyperplasia. Identification of the anatomical adrenal lesion causing hyperaldosteronism typically involves CT or MR scanning, with lateralisation of aldosterone production confirmed by adrenal vein sampling (AVS). The latter is a technically difficult and invasive procedure, but current non-invasive alternatives (e.g. radiolabelled i...

ea0021oc2.4 | Neuroendocrine tumours/pituitary | SFEBES2009

Geographical cluster of familial isolated pituitary adenoma kindreds with an identical AIP mutation

Ozfirat Zehra , Cain Josh , Chahal Harvinder , Stals Karen , Ellard Sian , Howlett Trevor , Levy Miles , Atkinson Brew , Morrison Patrick , Akker Scott , Grossman Ashley , Korbonits Marta

Mutations in the co-chaperone molecule AIP account for a predisposition to pituitary tumours in some families with familial isolated pituitary adenomas (FIPA). We now report on four apparently-unrelated families with the same mutation and originating from the same geographical area, suggesting a possible founder mutation.The index patient had gigantism (19 years, 208 cm) and had a female 4th cousin, once removed (13 years, 191 cm) with a large pituitary ...

ea0021oc2.5 | Neuroendocrine tumours/pituitary | SFEBES2009

Differential effects of oestrogen on hypothalamic GnRH-I and GnRH-II gene expression in female rhesus macaques

Urbanski Henryk , Eghlidi Dominique , Kohama Steven

In mammals, the preovulatory LH surge is thought to be triggered by enhanced release of GnRH into the hypothalamic–pituitary portal blood vessels. Recently, we discovered that the medial basal hypothalamus (MBH) of rhesus macaques (Macaca mulatta) contains two distinct populations of GnRH-producing neurones. One of these populations expresses the traditional mammalian form of GnRH (i.e. GnRH-I) while the other expresses a more conserved vertebrate form of GnRH (i.e...

ea0021oc2.6 | Neuroendocrine tumours/pituitary | SFEBES2009

Laying the foundation for neuroendocrine control of human reproduction: an investigation into the development of kisspeptin and neurokinin B networks

Tello Javier , George Jyothis , Millar Mike , Anderson Richard , Millar Robert

The development and maturation of kisspeptin neurons is critical for activating GnRH release needed to initiate puberty. However, little is known of the development and organization of kisspeptin neurons in the human hypothalamus and the anatomical architecture of kisspeptin neurons in rodents is distinct from that of primates.The aim of the present study was to examine the development of the hypothalamic neuroendocrine circuitry that sets the structural...

ea0021oc2.7 | Neuroendocrine tumours/pituitary | SFEBES2009

The spectrum of disease in diazoxide responsive hyperinsulinaemic hypoglycaemia

Skae Mars , Amin Rakesh , Patel Leena , Gleeson Helena , Ehtisham Sarah , Didi Mohammed , Blair Jo , Das Urmi , Rigby Lindsey , Blankenstein Oliver , Ellard Sian , Kelsey Anna , Clayton Peter , Banerjee Indraneel , Hall Catherine

: Hyperinsulinaemic hypoglycaemia (HH) has traditionally been classified according to clinical response to diazoxide, with milder diazoxide responsive (DRHH) and severe unresponsive cases. Loss-of-function mutations in ATP-sensitive potassium (KATP) channel genes (ABCC8 and KCNJ11), are the commonest cause for HH. In severe HH, genetic analysis and pancreatic imaging assist in differentiating diffuse from focal forms of HH, as the latter may be cured b...

ea0021oc2.8 | Neuroendocrine tumours/pituitary | SFEBES2009

Diagnosis and localisation of insulinoma: the value of modern MRI in conjunction with calcium stimulation catheterisation

Muthuppalaniappan Vasantha M , Druce Maralyn R , O'Leary Benjamin , Chew Shern L , Drake William M , Monson John P , Akker Scott A , Besser Michael , Sahdev Anju , Rockall Andrea , Vyas Soumil , Matson Matthew , Berney Daniel , Bhattacharya Satya , Grossman Ashley B

Objective: To review the diagnostic features and localization accuracy of different investigations for insulinomas diagnosed 1990–2009 at a single tertiary referral centre.Design: A cross-sectional, restrospective analysis, including sporadic tumours and those in multiple endocrine neoplasia syndromes.Methods: Case notes and investigation results were reviewed from patients with biochemically or histologically-proven insulinom...