Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 21 | SFEBES2009 | Next issue

Society for Endocrinology BES 2010

Poster Presentations

Cytokines and growth factors

ea0021p121 | Cytokines and growth factors | SFEBES2009

Peripheral blood mononuclear cells from active rheumatoid arthritis patients show a defective induction of adrenomedullin

Green Laura , Berry Andrew , Donn Rachelle , Ray David

Rheumatoid arthritis (RA) is a common chronic systemic inflammatory disease. Several new therapies exist for RA but long-term patient management remains problematic.We have discovered that hypoxia, a characteristic of inflamed tissues, potently inhibits glucocorticoid (Gc) sensitivity. This effect is mediated, in part by HIF1α, whose activity is induced in hypoxia. HIF1α gene expression is also induced in primary peripheral blood mononuclear ce...

ea0021p122 | Cytokines and growth factors | SFEBES2009

Impact of adiposity on dynamic changes of serum adipokines after OGTT

Banerjee Moulinath , Pemberton Phillip , Charlton-Menys Valentyn , Fraser William , Cruickshank Kennedy

Introduction: Data are conflicting on whether and how serum adipokines alter following acute dietary intake. Here, we used the specific challenge of standard 75 g glucose tolerance tests (GTT) to assess timed changes in TNF-α, IL-6, leptin and adiponectin in healthy younger women and how these would be affected by adiposity.Methods: Consenting participants in the Manchester Mothers’ Heart and Vascular health study had serum adipokines measured ...

ea0021p123 | Cytokines and growth factors | SFEBES2009

Interaction of endothelin, aldosterone and bone morphogenetic proteins on mitotic actions of pulmonary arterial smooth muscle cells isolated from pulmonary arterial hypertension

Otsuka Fumio , Yamanaka Ryutaro , Nakamura Kazufumi , Yamashita Misuzu , Takeda Masaya , Suzuki Jiro , Miyoshi Tomoko , Inagaki Kenichi , Makino Hirofumi

Primary arterial hypertension (PAH) is a life-threatening disease that has prevalence of 1 to 2 occurrences per one million individuals. This disease is characterized by excessive proliferation of vascular endothelium and smooth muscle cells, causing thickening the walls of pulmonary arterioles. Recent studies have uncovered a link between familial and idiopathic PAH to BMPRII mutations. The pathology of PAH is characterized by the remodeling of pulmonary arteries due to pulmo...

ea0021p124 | Cytokines and growth factors | SFEBES2009

PTTG promotes mitogenic mechanisms in thyroid cells through autocrine pathways of interaction with TGF-α, EGF and IGF1

Lewy Greg , Ryan Gavin , Read Martin , Smith Vicki , Fong Jim , Warfield Adrian , Eggo Margaret , Seed Robert , Sharma Neil , Perkin Kwan , Franklyn Jayne , McCabe Christopher , Boelaert Kristien

The human pituitary tumor transforming gene (hPTTG) is overexpressed in thyroid cancers; it induces genetic instability and propagates growth through the induction of growth factors. We set out to investigate the autocrine and paracrine pathways of interaction between hPTTG and epidermal growth factor (EGF), transforming growth factor-α (TGF-α) and insulin-like growth factor 1 (IGF1) in vitro and in vivo. Synchronised K1 papillary thyroid carcinoma cell...

ea0021p125 | Cytokines and growth factors | SFEBES2009

Does SOCS2 mediate inflammatory induced growth retardation?

Pass Chloe , MacRae Vicky , Ahmed Syed , Farquharson Colin

Introduction: SOCS2 is an important negative regulator of post-natal growth, as demonstrated by the SOCS2 null overgrowth phenotype. We have used SOCS2−/− mice, alongside chondrocytes overexpressing SOCS2, to investigate the mode of action of SOCS2 at the epiphysis. SOCS2 maybe involved in growth retardation associated with chronic inflammatory disorders, therefore we studied LPS induced growth retardation in wild type (WT) and SOCS2−/−<...

ea0021p126 | Cytokines and growth factors | SFEBES2009

Differential effects of eicosapentaenoic acid (EPA) and palmitate on tumour necrosis factor (TNF-α) and insulin-like growth factor (IGF1) action in murine skeletal muscle cells

Saini Amarjit , Al-Shanti Nasser , Stewart Claire

Introduction: Sarcopenic obesity prevails with ageing, encompassing excess weight gains and muscle mass or strength losses. Free fatty acids and proinflammatory cytokines are elevated in obese adults. Palmitate decreases the anabolic effects of IGF signalling, while EPA elicits anti-inflammatory activities.We aimed to examine the effects of palmitate and EPA on TNF-α/IGF1 interactions in established models of skeletal muscle cell loss.<p class="...

ea0021p127 | Cytokines and growth factors | SFEBES2009

Atrophy or hypertrophy: differential responses of C2 and C2C12 mouse skeletal myoblasts in the absence or presence of tumour necrosis factor-α (TNF-α)

Sharples Adam , Al-Shanti Nasser , Stewart Claire

Inflamed ageing is associated with reduced muscle mass and increased susceptibility to TNF-induced muscle protein degradation. We therefore aimed to elucidate mechanisms supporting reduced hypertrophy and increased atrophy of skeletal myoblasts. C2 myoblasts display diminished differentiation and increased susceptibility to TNF-α-induced apoptosis versus daughter C2C12 cells, providing us with relevant models. C2 and C2</su...

ea0021p128 | Cytokines and growth factors | SFEBES2009

Blood pressure, renal cytokines and biochemical parameters improve in morbidly obese patients after bariatric surgery

Dubb Sukhpreet Singh , Bueter Marco , Gill Abhijit , Ahmed Ahmed R , Frankel Andrew , Le Roux Carel W , Tam Frederick

Introduction: Obesity related glomerulopathy (ORG) is an emerging epidemic alongside increasing incidences of obesity. ORG pathophysiology has not been explored despite poor prognosis in untreated patients. MCP-1, MIF, CCL-18 and CCL-15 are novel cytokines that may be pathologically involved in obesity-induced renal injury and explored in this study.Methods: Blood pressure, urine and blood samples were collected from 34 morbidly obese patients before and...